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ProteomicsAn engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, Tyr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD067251 | Pride
Neuroblastoma Sh-sy5y Insulin analog Human Lc-ms/ms 
TranscriptomicsIPC knockout, 14 day old female flies, 48h yeast feeding
Background Insulin signaling pathway is conserved from worms to humans. In Drosophila, three insulin-like peptides (dilps) are expressed in the insulin producing cells (IPCs) in the brain. In order to identify target genes of insulin signaling, the IPCs of female flies were destroyed during develop...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-10625 | biostudies-arrayexpress
UnknownNovel four-disulfide insulin analog with high aggregation stability and potency.
Not available
S-EPMC7012051 | biostudies-literature
UnknownInsulin analog with additional disulfide bond has increased stability and preserved activity.
Not available
S-EPMC3595460 | biostudies-literature
UnknownA forskolin-conjugated insulin analog targeting endogenous glucose-transporter for glucose-responsive insulin delivery.
Not available
S-EPMC7148115 | biostudies-literature
UnknownPitfalls in Diagnosing Hypoglycemia Due to Exogenous Insulin: Validation and Utility of an Insulin Analog Assay.
Not available
S-EPMC9996747 | biostudies-literature
TranscriptomicsExpression data from Min6 cells maintained under different culture conditons that affect Hes3 expression and localization
The basic helix-loop-helix (bHLH) transcription factor hairy and enhancer of split (Hes3) is a member of the Hes/Hey gene family that regulates developmental processes in progenitor cells from various tissues. We demonstrated the Hes3 expression in mouse pancreatic tissue, suggesting it may have a r...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-64444 | biostudies-arrayexpress
TranscriptomicsGene expression data from Min6 cells grown in serum containing and serum free condtions following Hes3 knock down
The basic helix-loop-helix (bHLH) transcription factor hairy and enhancer of split (Hes3) is a member of the Hes/Hey gene family that regulates developmental processes in progenitor cells from various tissues. We demonstrated the Hes3 expression in mouse pancreatic tissue, suggesting it may have a r...
ORGANISM(S): Mus musculus 
2014-12-23 | E-GEOD-64449 | biostudies-arrayexpress
UnknownExpression of the Biologically Active Insulin Analog SCI-57 in Nicotiana Benthamiana.
Not available
S-EPMC6868099 | biostudies-literature
UnknownCorrelates of analog vs human basal insulin use among individuals with type 2 diabetes: A cross-sectional study.
Not available
S-EPMC8217374 | biostudies-literature
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