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MetabolomicsApolipophorin-III modulates antiviral defense in Bombyx mori: an integrated transcriptomic and lipidomic analysis of its inhibitory role against BmNPV infection.

The silkworm (Bombyx mori) is an economically important insect and a lepidopteran model organism. Controlling viral infections is crucial for the sustainable development of sericulture. Bombyx mori nucleopolyhedrovirus (BmNPV) infection can cause large-scale mortality in silkworm populations. Ins...

2025-12-03 | MTBLS13447 | MetaboLights
ProteomicsGlobal, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice
The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic 𝛽-cells12. Yet, the relevance of 𝛽-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demons...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-12 | PXD048652 | Pride
Insulin inhibitory receptor Inceptor Diet-induced obesity Glucose homeostasis Insulin 
ProteomicsGlobal, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice
The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic 𝛽-cells12. Yet, the relevance of 𝛽-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demons...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD046256 | Pride
Insulin inhibitory receptor Inceptor Insulin inceptor Diet-induced obesity Glucose homeostasis 
ProteomicsInceptor binds and directs insulin to lysosomal degradation in -cells
Blunted first-phase insulin secretion and insulin deficiency are early signs of -cell dysfunction and diabetes manifestation. Thus, insights into molecular mechanisms that regulate insulin homeostasis might provide entry sites to replenish insulin content and restore -cell function. Here, we identif...
ORGANISM(S): Homo sapiens (Human) 
2024-09-09 | PXD040758 | Pride
Cdms Inceptor 
TranscriptomicsNutritional Strategy to Prevent Fatty Liver and Insulin Resistance Independent of Obesity by Reducing GIP Responses
High intakes of carbohydrates, particularly sucrose, in Western societies are associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related to the carbohydrate quantity or the hormonal responses, particularly Glucose-dependent Insuli...
ORGANISM(S): Mus musculus 
2014-12-05 | E-GEOD-54723 | biostudies-arrayexpress
ProteomicsA Fbxo48 inhibitor prevents pAMPKa degradation and ameliorates insulin resistance
Beas-2b cells treated with vehicle or BC1618 compound, which targets the ubiquitin E3 ligase for targeted degradation of pAMPKa protein. Cell lysate was subjected to mass spectrometry for phosphoproteomics to uncover alterations in the phosphoproteome.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-20 | MSV000086334 | MassIVE
GenomicsThe obesity-linked peptide SP16 regulates adipocytes through GIP and insulin receptor
The obesity-linked peptide SP16 regulates adipocytes through GIP and insulin receptor
PRJNA1297185 | ENA
TranscriptomicsTranscription profiling of white adipose tissue from Lldlr-/- and Lldlr-/-Mif-/- mice
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs development of insulin resistance, glucose intolerance and associated atherosclerotic disease
ORGANISM(S): Mus musculus 
2009-06-19 | E-TABM-524 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J strain.
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain more insight in the role of the small intestine in the etiology of these metabolic disorders, a microarray study was performed on small intestines (SI) of C57BL/6J mice that were fed a high fat diet ...
ORGANISM(S): Mus musculus 
2008-06-20 | E-GEOD-8582 | biostudies-arrayexpress
GenomicsOrexin/Hypocretin Receptor 2 Signaling in MCH Neurons Regulates REM sleep and Insulin Sensitivity
Orexin/Hypocretin Receptor 2 Signaling in MCH Neurons Regulates REM sleep and Insulin Sensitivity
PRJNA1182770 | ENA
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