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UnknownNeurexin-1α contributes to insulin-containing secretory granule docking.
Not available
S-EPMC3307300 | biostudies-literature
UnknownSecretory stimuli distinctly regulate insulin secretory granule maturation through structural remodeling.
Not available
S-EPMC12435921 | biostudies-literature
UnknownThe Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.
Not available
S-EPMC5624795 | biostudies-literature
ProteomicsPurification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging
Endocrine cells employ regulated exocytosis of secretory granules to secrete hormones and neurotransmitters. Secretory granule exocytosis depends on spatio-temporal variables such as proximity to the plasma membrane and age, with newly-generated granules being preferentially released. Despite recent...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-04-15 | PXD050087 | Pride
Arhg Proteomics Lipidomics Clip tag Insulin granule Kif5b Rab3a Organelle purification 
UnknownSequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs.
Not available
S-EPMC8449372 | biostudies-literature
ProteomicsCab45-dependent facilitation of insulin secretory granule biogenesis and its dysregulation in type 2 diabetes
Germanos M1*. Yau B1*. Taper M1. An Y1. Yeoman C1. Wilson A1. Cattin-Ortolá J2. Maslar D3. Tong J1. Naghiloo S1. Needham E4. Diaz-Vegas A4. Larance M1. Thomas H5. Seidah NG6. von Blume J7. James DE4. Thorn P1. Ailion M2. Asensio C3. Kebede MA1. 1 School of Medical Sciences, Charles Perkins Centre, ...
ORGANISM(S): Rattus rattus (Black rat) 
2024-12-02 | PXD052042 | Pride
Islet Cab45 Insulin 
ProteomicsProteomics of Enriched Insulin Secretory Granules Fractionated by Size Exclusion Chromotography
Hybrid insulin peptides (HIPs) form in pancreatic beta-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs, which have been confidently identified in pancreatic islets by mass spectrometry, are targeted by CD4 T cells in subjects with Type 1 Diabetes (T...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-16 | PXD032664 | Pride
Beta cell Proteins Insulin secretory granule Proteases 
UnknownMapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET.
Not available
S-EPMC2920663 | biostudies-literature
UnknownDistinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.
Not available
S-EPMC7738183 | biostudies-literature
UnknownSpatiotemporal Analysis of Glucagon Secretory Granule Dynamics.
Not available
S-EPMC12457985 | biostudies-literature
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