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GenomicsHIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort.
Distinct integration patterns of different retroviruses have puzzled virologists for over 20 years. The viral integrase (IN), as part of the intasome complex, docks onto the target DNA (tDNA) and catalyzes the insertion of the viral genome into the host chromatin. We identified retroviral IN amino a...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-61003 | biostudies-arrayexpress
TranscriptomicsCLIP-seq analysis of integrase-RNA interactions
Integrase CLIP-seq experiments were conducted on wild-type and eccentric HIV-1 virions generated in the presence of allosteric integrase inhibitors and IN K264/266A and R269/K273A mutations Integrase CLIP-seq experiments were conducted by immunoprecipitation of integrase-RNA complexes from fully for...
ORGANISM(S): Human Immunodeficiency Virus 1 
2016-08-25 | E-GEOD-83588 | biostudies-arrayexpress
GenomicsCharacterization of attB and core-attP recombination sites of the integrase from Lactobacilus delbrueckii subsp. bulgaricus bacteriophage mv4
Different attB or attP DNA libraries containing 7-bp random nucleotides were used for in vitro recombination mediated by the purified integrase from mv4 bacteriophage against their cognate wild-type attB or attP recombination site.
ORGANISM(S): Lactobacillus delbrueckii subsp. bulgaricus 
2023-12-10 | E-MTAB-13571 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cord lining epithelial cells after phage integrase mediated integration
The two obstacles that impede a wider application of genetically modified cells expressing therapeutic transgenes for ex vivo gene therapy are the immune mediated rejection of the transplanted cells, combined with their potential to cause iatrogenic oncogenesis. In this study we describe a new cellu...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12510 | biostudies-arrayexpress
TranscriptomicsAnalysis of copy number change in cord lining epithelial cells after phage integrase mediated genomic integration.
The two obstacles that impede a wider application of genetically modified cells expressing therapeutic transgenes for ex vivo gene therapy are the immune mediated rejection of the transplanted cells, combined with their potential to cause iatrogenic oncogenesis. In this study we describe a new cellu...
ORGANISM(S): Homo sapiens 
2008-09-01 | E-GEOD-12629 | biostudies-arrayexpress
ProteomicsRetroelement Ty1 Integrase interactome identified using tandem chromatin affinity purification ( TChAP) after in vivo crosslink in yeast Saccharomyces cerevisiae
To identify yeast proteins associated with Ty1 integrase (IN) that could regulate Ty1 replication, we co-purified IN partners using the tandem chromatin affinity purification procedure after in vivo cross-link (TChAP), which we developed previously (Nguyen et al. 2014). We first identified RNA Pol I...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-11-17 | PXD027420 | Pride
Rna polymerase iii Yeast Ck2 Integrase Ty1 
TranscriptomicsCLIP-seq analysis of integrase-RNA interactions
Integrase CLIP-seq experiments were conducted on wild-type and eccentric HIV-1 virions generated in the presence of allosteric integrase inhibitors and IN K264/266A and R269/K273A mutations
ORGANISM(S): Human immunodeficiency virus 1 
2016-08-25 | GSE83588 | GEO
ProteomicsStructural bases for integrase-RNA binding and retention of viral RNA within HIV-1 capsid cores
HIV-1 integrase (IN) promotes encapsulation of viral genomic RNA into mature viral cores, and this function is a target for ongoing antiretroviral drug development efforts. We determined a cryo-EM structure of a primate lentiviral IN complexed with RNA, which revealed a linear filament made of IN oc...
ORGANISM(S): Simian immunodeficiency virus 
2025-12-04 | PXD070910 | Pride
Hiv-1 Hdx/ms Integrase Human Cryoem 
GenomicsHIV integrase deep sequencing.
Identification of minority resistance mutations in the HIV-1 integrase gene using Next Generation Sequencing
PRJEB9552 | ENA
ProteomicsHDX-MS of Importin 7 and C terminal of HIV-1 integrase complex
This project investigates the interaction between Importin 7 (Imp7), a nuclear transport receptor, and HIV-1 Integrase (IN), a viral enzyme essential for integration of viral DNA into the host genome. To characterize the molecular basis of this interaction, we performed hydrogen–deuterium exchange m...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD068263 | Pride
Karyopherins Hiv Nulear transport 
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