Integrin signaling

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Mus musculus (420)
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Organisms

Homo sapiens (184)
Mus musculus (184)
Rattus norvegicus (13)
Canis lupus familiaris (3)
Gallus gallus (3)
Danio rerio (3)
Ambystoma mexicanum (1)
Oryctolagus cuniculus (1)
Macaca fascicularis (1)
Mus (1)
Salmo salar (1)
Botryllus schlosseri (1)
Pinctada fucata (1)
Sus scrofa (1)
Anas platyrhynchos (1)
Macaca mulatta (1)
Drosophila melanogaster (1)

Repository

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geo (392)
pride (101)
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Tissue

Cell culture (23)
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Disease

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Not Available (2)
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Disease free (2)
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2h after infection with wildtype Streptococcus pyogenes (1)
Bordetella pertussis inoculated (1)
Reference (1)
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Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (1)
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Diabetes mellitus (1)
Adenocarcinoma (1)
B-cell lymphoma (1)
Chikungunya (1)
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Pertussis (1)
Vulva squamous cell carcinoma (1)

Technology Type

Mass Spectrometry (101)
Shotgun proteomics (56)
Bottom-up proteomics (16)
Affinity purification coupled with mass spectrometry proteomics (15)
Data-independent acquisition (8)
Data-dependent acquisition (6)
Mass spectrometry (5)
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Chemical cross-linking coupled with mass spectrometry proteomics (2)
ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 2000 (1)
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HDMSE (1)
SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (28)
Illumina HiSeq 2000 (8)
NextSeq 500 (8)
NextSeq 2000 (5)
Illumina HiSeq 2500 (5)
Illumina HiSeq 4000 (5)
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NA (3)
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ScanArray scanning hardware (2)
NextSeq 550 (2)
Real-time PCR Thermal Cycler (1)
MoFlo XDP (Beckman Coulter) or a FACSAria II (Becton Dickinson) (1)
Fluidigm C1 autoprep system (1)
Axon Instruments GenePix 4000B scanner (1)
FACS Aria II (1)
Qiagen RNeasy micro Kit (1)
BD FACSAria III (1)
GeneChip Fluidics Station 450 (1)
GeneChip Scanner 3000 (1)
SMARTerTM Ultra Low RNA Kit (1)
G2565AA DNA microarray scanner [Agilent] (1)
Flow cytometer (1)
Agilent Scanner G2505C (1)
Hybridization oven rotator for Agilent Microarray Hybridization Chambers (1)
NanoDrop ND-2000 (1)
Illumina NovaSeq X (1)
BGISEQ-500 (1)
Illumina MiSeq (1)

Publication Date

2026 (106)
2025 (93)
2024 (66)
2023 (66)
2010 (63)
2012 (61)
2014 (56)
2016 (55)
2015 (54)
2013 (54)
2022 (52)
2021 (46)
2008 (45)
2011 (44)
2020 (36)
2017 (29)
2019 (27)
2009 (23)
2007 (23)
2018 (20)
2005 (4)
2006 (2)
2004 (1)

UNIPROT ID/AC

Q9Y210 (4)
Q8N699 (4)
P21731 (4)
Q8N9U0 (4)
Q15762 (4)
Q5VY43 (4)
Q8WWA1 (4)
Q9H7M9 (4)
O43561 (4)
P42680 (4)
Q9Y2L6 (4)
Q9UN19 (4)
Q68D51 (4)
Q9H4X1 (4)
Q9UIB8 (4)
Q5SQ64 (4)
Q684P5 (4)
P18433 (4)
O95866 (4)
O75563 (4)
Q99704 (4)
Q9NZM3 (4)
Q99576-3 (4)
Q99719-2 (4)
Q96K49 (4)
Q92835 (4)
Q7L591 (4)
Q6ZNJ1 (4)
Q13976-2 (4)
Q13976 (4)

CHEBI ID

CHEBI:16020 (3)
CHEBI:16704 (3)
CHEBI:28834 (3)
CHEBI:16359 (3)
CHEBI:17385 (3)
CHEBI:16827 (3)
CHEBI:16737 (3)
CHEBI:18257 (3)
CHEBI:17596 (3)
CHEBI:30769 (3)
CHEBI:16335 (3)
CHEBI:21557 (2)
CHEBI:37098 (2)
CHEBI:74000 (2)
CHEBI:84563 (2)
CHEBI:58148 (2)
CHEBI:18186 (2)
CHEBI:16244 (2)
CHEBI:172453 (2)
CHEBI:9907 (2)
CHEBI:27905 (2)
CHEBI:84822 (2)
CHEBI:24149 (2)
CHEBI:17140 (2)
CHEBI:43580 (2)
CHEBI:70984 (2)
CHEBI:35704 (2)
CHEBI:28238 (2)
CHEBI:89461 (2)
CHEBI:52449 (2)

Metabolite Name

Ursodeoxycholic acid (3)
O-Tyrosine (3)
Mesaconic acid (3)
Cholic acid (3)
Hydroxyphenyllactic acid (3)
Tetradecanedioic acid (3)
Citric acid (3)
Inosine (3)
Uridine (3)
2-Aminonaphthalene (2)
6-Hydroxynicotinic acid (2)
3-Methylhistidine (2)
Indoleacetic acid (2)
4-Hydroxyphenylpyruvic acid (2)
3-Methyladenine (2)
Dimethylglycine (2)
2'-O-methylcytidine (2)
5'-Methylthioadenosine (2)
Isocitric acid (2)
Ornithine (2)
N-Acetylputrescine (2)
Isovalerylglycine (2)
Citrulline (2)
Stearic acid (2)
Citraconic acid (2)
2-Hydroxy-2-methylbutyric acid (2)
4-Hydroxybenzoic acid (2)
3-Hydroxybutyric acid (2)
Trans-Aconitic acid (2)
Hexadecanedioic acid (2)

First Public Date

2026 (89)
2025 (61)
2024 (59)
2014 (55)
2023 (46)
2022 (32)
2021 (25)
2020 (19)
2017 (17)
2019 (16)
2015 (11)
2018 (5)
2016 (5)
2013 (4)

Modelling Approach

Ordinary differential equation model (2)

Lab affiliation

Head of the Curie Institute Mass Spectrometry Platform (4)
UHN (3)
Aarhus University Department of Biomedicine DK-8000 Aarhus (3)
Department of Molecular Biology and Genetics, Aarhus University, Denmark (2)
Korea Institute of Science and Technology (2)
Department of Molecular, Cellular and Developmental Biology. Yale University, 260 Whitney Ave, New Haven, CT. 06520, USA (2)
PROFESSOR, PRINCIPLE INVESTIGATOR, PROTEOMICS LAB, DEPARTMENT OF BIOSCIENCES AND BIOENGINEERING, IIT BOMBAY (1)
Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea (1)
Medimmune LLC (1)
Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University (1)
Department of chemistry and biochemistry, Texas Tech University, Lubbock, Texas, USA, 79413. (1)
Departments of Surgery and Biomedical Sciences Cedars-Sinai Medical Center (1)
Department of Pathology and Molecular Pathology, University Hospital Zürich and University of Zürich, Zürich, Switzerland (1)
Toxicology, ZFA Proteomics, Medical School Hannover, Germany (1)
Unité de recherche en biologie et épidémiologie parasitaires (URBEP) – UMR6236 – IFR48, Institut de Recherche Biomédicale des Armées (IRBA), antenne Marseille, URMITE UMR 6236, GSBdD de Marseille Aubagne, 111 avenue de la corse BP 40026, 13568 Marseille cedex 02, France. (1)
Department of Vascular Dysfunction, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Straße 7-11, 68167 Mannheim, Germany. Department of Vascular Dysfunction, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University, Ludolf-Krehl-Straße 7-11, 68167 Mannheim, Germany. (1)
Dept. of Molecular Hematology, Sanquin Research, Amsterdam, the Netherlands, and Landsteiner Laboratory, University of Amsterdam, Amsterdam, the Netherlands (1)
German Cancer Research Center DKFZ (1)
Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy (1)
UNC Neuroscience Center, Cell Biology and Physiology, The University of North Carolina at Chapel Hill (1)
Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milano; Italy (1)
Institute of Bioinformatics , International Technology Park, Bangalore, India (1)
Institute of Biological Chemistry, Academia SInica, Taiwan (1)
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India (1)
Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724 Asthma and Airway Disease Research Center, Tucson, AZ 85724 (1)
Mol & Med. Pharmacology (1)
Professor, Unversity of British Columbia (1)
CRCM (Marseille Protéomique), Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université, UM105, CNRS UMR7258, Marseille (1)
University of Vienna, Faculty of Chemistry, Joint Metabolome Facility, Department of Analytical Chemistry (1)
Centre for Neuroscience & Stereology, Neurological Department, Bispebjerg Hospital, Denmark (1)

IsPrivate

False (2)

Model Flag

Non Kinetic (1)

Modification

6-dioxaoctanediamine derivatized cysteine (1)

Study type

Transcription profiling by array (316)
RNA-seq of coding RNA (61)
ChIP-seq (20)
RNA-seq of coding RNA from single cells (18)
ATAC-seq (6)
Unknown experiment type (5)
Other (5)
Methylation profiling by high throughput sequencing (4)
RNA-seq of total RNA (4)
Animal - High-throughput sequencing (3)
Methylation profiling by array (3)
Baseline (2)
RNAi profiling by array (2)
Transcription profiling by RT-PCR (2)
Comparative genomic hybridization by array (2)
ChIP-chip by SNP array (1)
Animal - One-color microarray (1)
ChIP-chip by tiling array (1)
Cell line - High-throughput sequencing (1)
ChIP-chip by array (1)
ScATAC-seq (1)
RNA-seq of non coding RNA (1)

Release Date

2025 (325)
2022 (302)
2021 (294)
2023 (272)
2020 (252)
2016 (232)
2019 (230)
2017 (219)
2018 (217)
2014 (205)
2015 (204)
2024 (203)
2012 (178)
2013 (172)
2010 (166)
2011 (143)
2009 (111)
2008 (106)
2007 (71)
2026 (60)
2006 (32)
2005 (20)
2004 (16)
2003 (16)
2002 (11)
2001 (7)
2000 (6)
1999 (5)
1998 (4)
1994 (1)

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Transcription profiling of mouse C2C12 myoblast induced with tetracycline to enhance integrin alpha7 expression

Analysis of C2C12 myoblast induced with tetracycline to enhance integrin alpha7 expression. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dystrophy. Results of this s...

ORGANISM(S): Mus musculus

2008-06-16 | E-GEOD-8312 | biostudies-arrayexpress

Geier2011 - Integrin activation

Geier2011 - Integrin activation Rule based model that integrates the available data to test the biololical hypotheses regarding the role of talin, Dok1 and PIPKI in integrin activation. This model is described in the article: A co...

2014-03-05 | MODEL1208280001 | BioModels

Gene expression in b1-integrin wild-type and knockout mouse heart

Growth and expansion of ventricular chambers is essential during cardiogenesis and is achieved by proliferation of cardiac progenitors that are not fully differentiated. Disruption of this process can lead to prenatal lethality. In contrast, adult cardiomyocytes achieve growth through hypertrophy ra...

ORGANISM(S): Mus musculus

2009-01-14 | E-GEOD-14411 | biostudies-arrayexpress

Mesenchymal stem cell integrin-associated complexes

The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2016-07-20 | MSV000079956 | MassIVE

Transcription profiling of mouse skeletal muscle of integrin alpha7 overexpressing animals vs controlls

Analysis of integrin alpha7 transgenic mice skeletal muscle transcription profiles comparing to wild type controls. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dyst...

ORGANISM(S): Mus musculus

2008-06-16 | E-GEOD-8313 | biostudies-arrayexpress

sVEGFR-1 signaling through Î±5Î²1 integrin

Soluble VEGFR-1 (sVEGFR-1) acts both as a decoy receptor for VEGFs and as an extracellular matrix protein for Î±5Î²1 integrin. A sVEGFR-1-derived peptide that interacts with Î±5Î²1 integrin promotes angiogenesis. However, canonical signal downstream integrin activation is not induced, resulting into...

ORGANISM(S): Homo sapiens

2014-01-20 | E-GEOD-32560 | biostudies-arrayexpress

Ikaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia

Deletion of the Ikaros DNA-binding domain generates dominant-negative isoforms that interfere with Ikaros family activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemias (B-ALL). Here, we show that conditional inactivation of the Ikaros DNA binding domain i...

ORGANISM(S): Mus musculus

2014-02-09 | E-GEOD-53401 | biostudies-arrayexpress

Integrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

We have found that thyroid hormones (THs), acting as soluble integrin αvβ3 ligands, activate growth-related signaling pathways in T-cell lymphomas (TCL). Specifically, TH-activated αvβ3 integrin signaling promotes TCL proliferation and angiogenesis, in part, via the up-regulation of VEGF. CUTLL1 cel...

ORGANISM(S): Homo sapiens

2015-02-18 | E-GEOD-63122 | biostudies-arrayexpress

Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1.

Not available

S-EPMC4966988 | biostudies-literature

HER2d16 promotes breast cancer metastasis through integrin-driven signaling

PRJNA1422220 | ENA

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