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ProteomicsEASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification
We developed EASI-tag (Easily Abstractable Sulfoxide-based Isobaric tag), a new generation of amine-derivatizing and sulfoxide-containing isobaric labelling reagents, which dissociate at low collision energy and generate peptide-coupled, interference-free reporter ions with high yield. Efficient iso...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2018-06-21 | PXD007165 | Pride
Isobaric labeling Proteomics Mass spectrometry 
UnknownInterference-free proteome quantification with MS/MS-based isobaric isotopologue detection.
Not available
S-EPMC3993960 | biostudies-literature
ProteomicsTMTPro Complementary Ion Quantification Increase Plexing and Sensitivity for Accurate Multiplexed Proteomics at the MS2 level
The ability of the TMTPro isobaric labeling reagents to form complementary ions for accurate multiplexed proteomics at the MS2 level was investigated. Human and yeast peptides were labeled in distinct ratios to analyze the effect of interference on the quantification accuracy. A method, TMTProC, was...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2021-05-11 | PXD021661 | Pride
Complementary ion quantification Interference-free quantification Multiplexing Tmtpro 
UnknownMarker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images.
Not available
S-EPMC3831548 | biostudies-literature
ProteomicsProton Transfer Charge Reduction Enables Isobaric Labeling-Based Proteoform Quantification of Overlapping Signals in Top-Down Mass Spectrometry
Top-down mass spectrometry provides a powerful approach for analyzing and quantifying intact proteoforms, i.e., the distinct molecular forms of proteins. Isobaric labeling-based quantification strategies offer the advantages of multiplexing and increased analytical depth. However, a major challenge ...
ORGANISM(S): Bos taurus (Bovine) Gallus gallus (Chicken) 
2026-06-08 | PXD074730 | Pride
Proton transfer charge reduction Top-down proteomics Isobaric labeling Proteoform Quantification 
ProteomicsRatio accuracy evaluation and correction using tandem mass tags
The multiplexing capabilities of isobaric mass tag based protein quantification, such as Tandem Mass Tags (TMT) or Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) have dramatically increased the scope of Mass Spectrometry (MS) based proteomics studies. Not only does the technology allow ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-27 | MSV000082855 | MassIVE
UnknownOrthogonal gap-enhanced Raman tags for interference-free and ultrastable surface-enhanced Raman scattering.
Not available
S-EPMC11501518 | biostudies-literature
ProteomicsA multiplex fragment ion-based method for accurate proteome quantification
We developed a multiplex pseudo-isobaric dimethyl labeling (m-pIDL) method for proteome quantification to extend the capacity of the fragment ion-based method to 6-plex by one-step dimethyl labeling with several millidalton and dalton mass differences between precursor ions and enlarging the isolati...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2019-01-22 | PXD012457 |
UnknownInterference-free electron probe micro-analysis of bromine in halogen-bearing minerals and glasses: high-resolution measurements and quantitative elemental mapping.
Not available
S-EPMC10549222 | biostudies-literature
ProteomicsRatio accuracy evaluation and correction using tandem mass tags
The multiplexing capabilities of isobaric mass tag based protein quantification, such as Tandem Mass Tags (TMT) or Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) have dramatically increased the scope of Mass Spectrometry (MS) based proteomics studies. Not only does the technology allow ...
ORGANISM(S): Homo sapiens (Human) 
2016-07-01 | PXD003346 | Pride
Hcd Tandem mass tags Quantitative mass spectrometry Label-free quantification 
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