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Perinuclear assembly of vimentin intermediate filaments induces cancer cell nuclear dysmorphia
Intermediate filaments are regulators organismal lifespan in C. elegans
Nuclear dysmorphia, characterized by crumpled or lobulated polymorphic nuclear shapes, has been used as an index for the malignant grades of certain cancers. The expression of vimentin, a type III intermediate filament protein, is a hallmark of the epithelial-to-mesenchymal transition. However, it r...
ORGANISM(S): Homo sapiens 
2024-11-15 | GSE279178 | GEO
A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte
Compartmentalization of organelles in space and time affects their functional state and enables higher order regulation of essential cellular processes. How organellar residence is maintained in a defined area of the cell remains poorly understood. In this study, we uncover a new role for intermedia...
ORGANISM(S): Homo sapiens (Human) 
2023-09-05 | PXD040760 | Pride
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