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Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a leading cause of hepatocellular carcinoma (HCC), prompting ongoing efforts to understand its mechanisms and develop targeted therapies. Although dietary interventions such as fasting influence tumor growth, the underlying mole...
2026-08-28 | MTBLS15484 | MetaboLights
To better understand the hepatic metabolic response to intermittent fasting in chickens, Red Junglefowl chickens were raised on ad libitum (AL) feed until 14 days of age and then kept on AL feeding, switched to chronic feed restriction (CR) to around 70% or switched to an intermittent fasting (IF) ...
ORGANISM(S): Gallus gallus 
Intermittent fasting (IF) improves metabolic health, in part by remodeling white adipose tissue (WAT), yet the underlying mechanisms remain elusive. Here, we show that IF induces coordinated neurovascular remodeling in visceral WAT, marked by increased angiogenesis and sympathetic innervation. Using...
ORGANISM(S): Mus musculus 
Intermittent fasting (IF) increases lifespan, decreases metabolic disease phenotypes, and cancer risk in model organisms, but the mechanisms mediating these effects are not fully characterized. In particular, the altered transcriptional programming has yet to be defined in key fasting responsive tis...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-30 | PXD015553 | Pride
This study explored methylation, clinical, and other molecular alterations longitudinally over the course of intermittent fasting in healthy women aged 30 to 60. Here, we present methylation data from three matched sample types - buccal, cervical, and blood - longitudinally over the course of six mo...
Objectives Intermittent fasting is an effective dietary intervention to combat metabolic disease. Here, we explore the adipose depot specific response to every-other-day fasting (EODF) in mice to identify mechanisms that underly the beneficial effects. Methods Male C57BL/6J mice were placed on a 12-...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-12 | PXD020255 | Pride
Transcriptome analysis of mouse heart under different intermittent fasting conditions
Intermittent fasting alters the spatiotemporal atlas of transcriptomes
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