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TranscriptomicsNuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans
We have recently shown that transcription initiation RNAs (tiRNAs) are derived from sequences downstream of transcription start sites. Here we report the identification of a second class of nuclear-specific ~17-18 nucleotide small RNA whose 3M-bM-^@M-^Y ends map precisely to the splice donor site of...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20664 | biostudies-arrayexpress
ProteomicsHomologous HipA-like kinases are controlled by internal translational initiation and genetic organisation
HipA-like kinases are widespread bacterial serine-threonine kinases, yet their regulatory mechanisms remain poorly understood. Here, we characterise two novel HipA-like systems, the monocistronic hipL and bicistronic hipIN, containing a HipS-like and a HIRAN domain. We show that hipL contains an int...
ORGANISM(S): Escherichia coli 
2025-12-15 | PXD065186 | Pride
Trna synthetase E. coli Toxin-antitoxin Hipbst Protein kinase Hipba 
TranscriptomicsmRNAs translated at eIF4F
Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end-dependent scanning to initiate translation, picornaviral, hepatitis C vi...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-62 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mRNAs that remained associated with polysomes isolated from human cells after infection with poliovirus
Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end- dependent scanning to initiate translation, picornaviral, hepatitis C viral, and a few cellular RNAs have been shown to be translated by internal ribosome entry, a mechanism that can operate in the prese...
ORGANISM(S): Homo sapiens 
2005-06-24 | E-SMDB-59 | biostudies-arrayexpress
ProteomicsMultiple cis acting polypyrimidine tract elements regulate a cooperative mechanism for Triticum mosaic virus internal ribosomal entry site activity=]
Diverse elements within the 5’ untranslated region of an mRNA can influence the translation efficiency at the main AUG codon. We previously identified a core picornaviral like Y16X11-AUG motif with 16-nt polypyrimidine CU-tract separated by an 11-nt spacer sequence from the 13th AUG codon recognized...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-05-04 | PXD031443 | Pride
Yx-aug Aug selection Ribosomal subunit Ires Triticum mosaic virus Translation initiation Polypyrimidine-tract 
ProteomicsLoss of function cancer associated mutations in the EIF4G2 non canonical translation initiation factor
Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed due to cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become partic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-21 | MSV000092704 | MassIVE
UnknownDevelopmentally regulated internal transcription initiation during meiosis in budding yeast.
Not available
S-EPMC5685637 | biostudies-literature
UnknownAn interaction between eIF4A3 and eIF3g drives the internal initiation of translation.
Not available
S-EPMC10639049 | biostudies-literature
TranscriptomicsRibosome profiling of early zebrafish embryos -- miRNA-mediated regulation during embryogenesis causes translational repression before mRNA decay
MicroRNAs regulate gene expression through deadenylation, repression and mRNA decay. However, the contribution of each mechanism in non-steady-state situations remains unclear. We monitored the impact of miR-430 on ribosome occupancy of endogenous mRNAs in wild type and dicer mutants lacking mature...
ORGANISM(S): Danio rerio 
2012-03-15 | E-GEOD-34743 | biostudies-arrayexpress
UnknownCharacterization of the internal translation initiation region in monoclonal antibodies expressed in Escherichia coli.
Not available
S-EPMC6885640 | biostudies-literature
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