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TranscriptomicsTranscription profiling analysis of human global and individual mRNA translational efficiencies
A cell synchronization protocol was established in which global and individual mRNA translational efficiencies could be examined. While global translational efficiency was reduced in mitotic cells, approximately 3% of mRNAs remained predominantly associated with large polysomes during mitosis, as de...
ORGANISM(S): Homo sapiens 
2005-10-31 | E-SMDB-2546 | biostudies-arrayexpress
TranscriptomicsIRES containing mRNAs and mitotic cell cycle
A cell synchronization protocol was established in which global and individual mRNA translational efficiencies could be examined. While global translational efficiency was reduced in mitotic cells, approximately 3% of mRNAs remained predominantly associated with large polysomes during mitosis, as de...
ORGANISM(S): Homo sapiens 
2005-12-30 | E-GEOD-3957 | biostudies-arrayexpress
ProteomicsRNA-protein interactome reveals essential roles of RPL5 and RNA helicase A in mediating translation from the Hepatitis E virus internal ribosome entry site-like element
Multiple processes exist in a cell to ensure continuousproduction of essential proteins either through cap-dependent or cap-independent translation processes. Viruses depend on the host translation machinery for viral protein synthesis. Therefore, viruses have evolved clever strategies to utilize th...
ORGANISM(S): Homo sapiens (Human) 
2023-06-25 | PXD031009 | Pride
Hepatitis e virus cap-independent translation  rna-protein interaction  virus-host interaction internal ribosome entry site Hev orf4. 
TranscriptomicsPolysome purified mRNA in control and RACK1 silenced in human hepatocarcinoma cells
Fighting viral infections is hampered by the scarcity of viral targets and their variability resulting in development of resistance. Viruses depend on cellular molecules for their life cycle, which are attractive alternative targets, provided that they are dispensable for normal cell functions. Usin...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60374 | biostudies-arrayexpress
ProteomicsMultiple cis acting polypyrimidine tract elements regulate a cooperative mechanism for Triticum mosaic virus internal ribosomal entry site activity=]
Diverse elements within the 5’ untranslated region of an mRNA can influence the translation efficiency at the main AUG codon. We previously identified a core picornaviral like Y16X11-AUG motif with 16-nt polypyrimidine CU-tract separated by an 11-nt spacer sequence from the 13th AUG codon recognized...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-05-04 | PXD031443 | Pride
Yx-aug Aug selection Ribosomal subunit Ires Triticum mosaic virus Translation initiation Polypyrimidine-tract 
TranscriptomicsTranscription profiling of mRNAs that remained associated with polysomes isolated from human cells after infection with poliovirus
Although most eukaryotic mRNAs need a functional cap binding complex eIF4F for efficient 5' end- dependent scanning to initiate translation, picornaviral, hepatitis C viral, and a few cellular RNAs have been shown to be translated by internal ribosome entry, a mechanism that can operate in the prese...
ORGANISM(S): Homo sapiens 
2005-06-24 | E-SMDB-59 | biostudies-arrayexpress
GenomicsThe long noncoding RNA Malat1 contains an internal ribosome entry site mediating micropeptide translation
The long noncoding RNA Malat1 contains an internal ribosome entry site mediating micropeptide translation
PRJNA1365748 | ENA
UnknownConformational inhibition of the hepatitis C virus internal ribosome entry site RNA.
Not available
S-EPMC2770845 | biostudies-literature
UnknownDiscovery of functional factorless internal ribosome entry site-like structures through virome mining.
Not available
S-EPMC12221177 | biostudies-literature
ProteomicsInternal Ribosome Entry Site RNAs act in trans through an antisense sequence
SINEUPs are antisense long non-coding RNAs (lncRNAs) that increase translation of overlapping mRNAs through the activity of two domains: an embedded SINEB2 sequence UP-regulates translation (Effector Domain) while the antisense region provides target specificity (Binding Domain). In this study, we ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD028571 | Pride
Proteomics Circ5533 Pxk Binding domain Sineups 
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