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ProteomicsSANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes
Splicing is catalyzed by the spliceosome, a compositionally dynamic complex assembled stepwise on pre-mRNA. We reveal links between splicing machinery components and the intrinsically disordered ciliopathy protein SANS. Pathogenic mutations in SANS/USH1G lead to Usher syndrome––the most common cause...
ORGANISM(S): Homo sapiens (Human) 
2021-05-25 | PXD023942 | Pride
Intra-nuclear transport Cajal bodies Ciliopathy Spliceosome Nuclear speckles Alternative splicing Usher syndrome 
TranscriptomicsGlobal changes in the nuclear positioning of chromatin domains and genomic interactions that orchestrate B cell fate
The genome is folded into domains that are located in either transcriptionally inert or permissive compartments. Here we used genome-wide strategies to characterize domains during B cell development. Structured Interaction Matrix Analysis revealed that CTCF occupancy was primarily associated with i...
ORGANISM(S): Mus musculus 
2012-10-09 | E-GEOD-40173 | biostudies-arrayexpress
UnknownHyperinvasive Meningococci Induce Intra-nuclear Cleavage of the NF-κB Protein p65/RelA by Meningococcal IgA Protease.
Not available
S-EPMC4524725 | biostudies-literature
ProteomicsImportin 7 - HIV-1 integrase LC-MS/MS
This project investigates the interaction between Importin 7 (Imp7), a nuclear transport receptor, and HIV-1 Integrase (IN), a key viral enzyme required for integration of the viral DNa to the host genome. Although Imp7 has been implicated in facilitating nuclear entry of the HIV-1 IN, the molecular...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD066885 | Pride
Hiv-1 Nuclear transport 
UnknownSubstrate-mediated remodeling of methionine transport by multiple ubiquitin-dependent mechanisms in yeast cells.
Not available
S-EPMC1589980 | biostudies-literature
UnknownThe essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits.
Not available
S-EPMC1253832 | biostudies-literature
UnknownA Begomovirus Nuclear Shuttle Protein-Interacting Immune Hub: Hijacking Host Transport Activities and Suppressing Incompatible Functions.
Not available
S-EPMC7156597 | biostudies-literature
ProteomicsProteomics of isolated rat manchettes
The manchette is a transient microtubular structure that plays a vital role in nuclear shaping during spermiogenesis. It comprises thousands of microtubules (MTs) that build a scaffold surrounding the distal half of the nucleus. The manchette distributes proteins and vesicles during spermiogenesis i...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-18 | PXD055902 | Pride
Manchette  imt  microtubules  actin  cell polarization Proteomics Cryo-et Spermatogenesis Spermiogenesis 
UnknownIntracavity Raman scattering couples soliton molecules with terahertz phonons.
Not available
S-EPMC9018723 | biostudies-literature
UnknownLiquid phase blending of metal-organic frameworks.
Not available
S-EPMC6004012 | biostudies-literature
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