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ProteomicsEvolutionarily Convergent Mechanism of Formin Regulation Coordinates Actin Polymerization in Apicomplexan Parasites
Apicomplexan parasites rely on actin-based motility for host cell invasion and for their dissemination. Although previous studies implicate formin 1 (FRM1) in governing this process in Toxoplasma, the mechanisms that position it at the cell apex and regulate its activity during the transition from i...
ORGANISM(S): Toxoplasma gondii ME49 
2025-11-04 | PXD068228 | Pride
Methylation Gliding motility Intramolecular regulation Autoinhibition Actin polymerization Formin 
ProteomicsIntramolecular disulfide bridges in Voltage-Dependent Anion Channel 2 (VDAC2) protein from Rattus norvegicus revealed by high resolution mass spectrometry.
Voltage-Dependent Anion Channel isoforms (VDAC1, VDAC2, VDAC3) are relevant component of the outer mitochondrial membrane and play crucial role in cellular processes, in regulation of metabolism and in survival pathways. Recently, we reported the characterization of the oxidation pattern of cysteine...
ORGANISM(S): Rattus rattus (Black rat) 
2024-06-16 | PXD044041 | Pride
High-resolution mass spectrometry  intramolecular disulfide bridges  rattus voltage-dependent anion selective channel isoform 2 (rvdac2)  cysteine redox state  structural characterization. 
UnknownIdentification of an intramolecular interaction important for the regulation of GIT1 functions.
Not available
S-EPMC2096589 | biostudies-literature
ProteomicsIntramolecular synergism and proteolytic control of bacteriophage endolysin PlySK1249
Endolysins are peptidoglycan hydrolases produced at the end of the bacteriophage (phage) replication cycle to lyse the host cell. Gram-positive phages endolysins come in a variety of multi-modular forms that combine different catalytic domains and may have evolved to adapt to their bacterial hosts. ...
ORGANISM(S): Streptococcus agalactiae FSL S3-026 Streptococcus dysgalactiae subsp. equisimilis SK1249 
2021-04-15 | PXD024020 | Pride
Endolysin Proteolysis Bacteriophage Lc-ms/ms 
UnknownRestriction of intramolecular rotation for functionalizing metal nanoclusters.
Not available
S-EPMC10430645 | biostudies-literature
UnknownDynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release.
Not available
S-EPMC5738438 | biostudies-literature
UnknownRegulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism.
Not available
S-EPMC3589414 | biostudies-literature
UnknownIntramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism.
Not available
S-EPMC11658767 | biostudies-literature
UnknownNMR structure reveals intramolecular regulation mechanism for pheromone binding and release.
Not available
S-EPMC64689 | biostudies-literature
ProteomicsRegulation of the PKD2 channel function and associated disease phenotypes by RASSF4
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common monogenic genetic disorders, caused by mutations in receptor PKD1 or ion channel PKD2, and is characterized by progressive renal cyst development with additional hepatic and extrarenal manifestations. As effective treatme...
ORGANISM(S): Homo Sapiens 
2026-02-13 | PXD074819 |
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