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ProteomicsLong term intrathecal administration of morphine vs baclofen: differences in CSF identified using multi-glycomics
CSF samples from patients that had long-term (>2years), intrathecal morphine or baclofen administered via an indwelling pump, and we performed proteomics and multi-glycomics via sequential release of polysialic acids, glycosaminoglycans, N-glycans and O-glycans from the same sample material.
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD023111 | Pride
Multi-glycomics Csf Intrathecal Morphine Long-term 
GenomicsA Biodistribution Study of OTV vs. ASO by Intravenous or Intrathecal Administration in Cynomolgus Monkeys
A Biodistribution Study of OTV vs. ASO by Intravenous or Intrathecal Administration in Cynomolgus Monkeys
PRJNA858409 | ENA
UnknownData from subjects receiving intrathecal laronidase for cervical spinal stenosis due to mucopolysaccharidosis type I.
Not available
S-EPMC4573094 | biostudies-literature
UnknownIntrathecal Morphine versus Intrathecal Hydromorphone for Analgesia after Cesarean Delivery: A Randomized Clinical Trial.
Not available
S-EPMC8754417 | biostudies-literature
TranscriptomicsA Biodistribution Study of OTV vs. ASO by Intravenous or Intrathecal Administration in Cynomolgus Monkeys
The objective of this study is to evaluate ASO biodistribution and pharmacodynamic response following intravenous delivery of conjugated OTV, which utilizes transferrin-receptor binding to deliver ASO, vs. intrathecal delivery of naked ASO in cynomolgus monkeys, the current gold standard for ASO del...
ORGANISM(S): Macaca fascicularis 
2024-02-12 | GSE208114 | GEO
TranscriptomicsSingle-nuclei RNA sequencing analysis from a WT mouse brain cortex after Intrathecal(IT) injection of AAV9/JeT-hSLC6A1 vector
Single-nuclei RNA sequencing analysis conducted at 6 months old from a WT mouse brain cortex, following Intrathecal(IT) injection of AAV9/JeT-hSLC6A1 vector at PND10.
ORGANISM(S): Mus musculus 
2025-01-08 | GSE278732 | GEO
UnknownBiodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration.
Not available
S-EPMC5072681 | biostudies-literature
GenomicsSingle-nuclei RNA sequencing analysis from a WT mouse brain cortex after Intrathecal(IT) injection of AAV9/JeT-hSLC6A1 vector
Single-nuclei RNA sequencing analysis from a WT mouse brain cortex after Intrathecal(IT) injection of AAV9/JeT-hSLC6A1 vector
PRJNA1168537 | ENA
ClinicalEffects of different doses of intrathecal morphine on quality of postoperative recovery in patients undergoing laparoscopic colorectal surgery
Interventions: 0.2mg morphine group:Intrathecal 0.2mg morphine + ropivacaine15mg;0.1mg morphine group:Intrathecal 0.1mg morphine + ropivacaine15mg;0.05mg morphine group:Intrathecal 0.05mg morphine + ropivacaine15mg;control group:Intrathecal ropivacaine15mg Primary outcome(s): Quality of Recovery-15 ...
81681 | ecrin-mdr-crc
UnknownIntrathecal sintilimab for leptomeningeal metastases of non-small cell lung cancer failed from targeted therapy and intrathecal chemotherapy (LMIS study).
Not available
S-EPMC12309713 | biostudies-literature
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