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TranscriptomicsTranscription profiling of human cervical cancer patient biopsies to explore intratumour heterogeneity reveals that intratumor variation is low for most probe sets tested but that multiple biopsies are recommended for reliable estimates of gene expression
To explore intratumor heterogeneity in gene expression profiles from patients with cervical cancer. Experimental Design: A total of 33 biopsies were obtained from 11 patients, sampling between two and five different areas for each tumor.The extracted RNA was hybridized onto the Affymetrix U133 Plus ...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-5787 | biostudies-arrayexpress
TranscriptomicsMethylome profiling of glioblastoma biopsies obtained by neuro-navigation in four distinct areas for 10 patients (necrotic zone, tumor zone, interface, and peripheral brain zone).
We classified samples and deciphered a key genes signature of intratumor heterogeneity by Principal Component Analysis and Weighted Gene Co-expression Network Analysis. We provide a signature of key cancer-heterogeneity genes highly associated with the intratumor spatial gradient and show that it is...
ORGANISM(S): Homo sapiens 
2016-09-19 | E-MTAB-5109 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of glioblastoma biopsies obtained by neuro-navigation in four distinct areas for 10 patients (necrotic zone, tumor zone, interface, and peripheral brain zone).
We classified samples and deciphered a key genes signature of intratumor heterogeneity by Principal Component Analysis and Weighted Gene Co-expression Network Analysis. Transcriptome analysis highlighted a pronounced intratumor architecture reflecting the surgical sampling plan of the study and iden...
ORGANISM(S): Homo sapiens 
2016-09-19 | E-MTAB-5092 | biostudies-arrayexpress
TranscriptomicsaCGH profiling of glioblastoma biopsies obtained by neuro-navigation in four distinct areas for 10 patients (necrotic zone, tumor zone, interface, and peripheral brain zone).
We classified samples and deciphered a key genes signature of intratumor heterogeneity by Principal Component Analysis and Weighted Gene Co-expression Network Analysis. At the genome level, we identified common GB copy number alterations and but a strong inter-individual molecular heterogeneity.
ORGANISM(S): Homo sapiens 
2016-09-19 | E-MTAB-5098 | biostudies-arrayexpress
TranscriptomicsIntratumor Heterogeneity and Precision of Microarray-Based Predictors of Breast Cancer Biology and Clinical Outcome
Genome-wide expression profiling was performed on 50 core needle biopsies from 18 breast cancer patients using Affymetrix GeneChip Human Genome Plus 2.0 Arrays. Global profiles of expression were characterized using unsupervised clustering methods and variance components models. Precision of predict...
ORGANISM(S): Homo sapiens 
2010-08-12 | E-GEOD-23593 | biostudies-arrayexpress
ProteomicsProteomic landscape of multi-layered breast cancer internal tumor heterogeneity
Breast cancer often presents with a high degree of intratumor heterogeneity, resulting in therapy resistance and tumor relapse. Here, we investigated spatial intratumor heterogeneity by integrating histopathological analyses and mass spectrometry-based proteomics. Using multilayered heterogeneity sc...
ORGANISM(S): Homo sapiens (Human) 
2025-08-10 | PXD024190 | Pride
Breast cancer Proteomics Intratumor heterogeneity Mass spectrometry 
GenomicsMultiplatform molecular profiling reveals epigenomic intratumor heterogeneity in ependymoma, DNA Methylation
Multiplatform molecular profiling reveals epigenomic intratumor heterogeneity in ependymoma, DNA Methylation
PRJNA596639 | ENA
GenomicsSpatially Annotated Single Cell Sequencing for Unraveling Intratumor Heterogeneity
Spatially Annotated Single Cell Sequencing for Unraveling Intratumor Heterogeneity
PRJNA804022 | ENA
TranscriptomicsProfiling by array of human Glioblastoma multiforme (GBM) tumor samples to asses the intra-tumoral heterogeneity in genomic copy number aberrations
Glioblastoma multiforme (GBM) is a highly heterogeneous disease that shows an wide range of genetic abnormalities in comparison to other astrocytic tumors. We have extracted between 4 and 8 tumor subsamples from different areas of the malignant tissue that were at least 1cm apart. Our aim to asses t...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1215 | biostudies-arrayexpress
ProteomicsProteomic analysis to examine the functional consequences of intratumor heterogeneity
To examine the functional consequences of intratumor heterogeneity, subclonal populations (SCPs) were derived from the MDA-MB-468 triple-negative breast cancer cell line. Characterization of these SCPs revealed considerable variation in SCP tumor forming capacity with SCP #32 (SCP32) having an excep...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD022325 | Pride
Subclonal population (scps) Intratumor heterogeneityr Human breast cancer cell line Tmt Proteomics Mass spectrometry Mda-mb-468 
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