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MetabolomicsIon mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain
Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging brain and aging-dependent disorders such as neurodegenerative diseases. There is an unmet demand to comprehensively profile sterol lipids spatially and temporally in different brain regions during aging. Here...
2021-05-24 | MTBLS2457 | MetaboLights
MetabolomicsA Novel Approach to Characterize the Lipidome of Marine Archaeon Nitrosopumilus maritimus by Ion Mobility Mass Spectrometry

Archaea are differentiated from the other two domains of life by their biomolecular characteristics. One such characteristic is the unique structure and composition of their lipids. Characterization of the whole set of lipids in a biological system (the lipidome) remains technologically challengi...

2021-12-16 | MTBLS3714 | MetaboLights
MetabolomicsTrapped ion mobilty improves annotation accuracy in LC-HRMS screening applications for exposomics

The widespread use of a large number of chemicals results in a significant exposure of humans and the environment, posing potential risks to human health and ecosystems. To assess the exposure to chemical mixtures, screening applications covering a large number of analytes based on liquid chromat...

2025-10-14 | MTBLS11753 | MetaboLights
ProteomicsOxonium Ion-Guided Ion Mobility-Assisted Glycoproteomics on the timsTOF Pro
Spatial separation of ions in the gas-phase, providing information about their size as collisional cross-sections, can readily be achieved through ion mobility. The timsTOF Pro combines a trapped ion mobility device with a quadrupole, collision cell and a time-of-flight analyser to enable the analys...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD034845 | Pride
Tims N-glycopeptides Oxonium ions Plasma Neutrophils Ion mobility 
ProteomicsHigh Field Asymmetric Waveform Ion Mobility Spectrometry in Non-targeted Bottom-up Proteomics of Dried Blood Spot
Dried Blood Spots samples are a rich source of proteins and have therefore great potential for proteomics biomarker discovery studies. Only a few articles have used DBS samples for non-targeted bottom-up protein analysis, probably due to the complexity of the DBS samples. Gas-phase separation by ion...
ORGANISM(S): Homo sapiens (Human) 
2018-05-03 | PXD007926 | Pride
Faims Dried blood spot Non-targeted Bottom-up Proteomics 
ProteomicsCyclic ion mobility for hydrogen/deuterium exchange-mass spectrometry applications
Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful tool to probe protein dynamics. As a bottom-up technique, HDX-MS provides information at peptide-level resolution, allowing structural localisation of dynamic changes. Consequently, HDX-MS data quality is largely determ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-04-08 | PXD048293 | Pride
Mass spectrometry Cyclic ion mobility Membrane proteins Hdx-ms Hydrogen/deuteirum exchange 
ProteomicsAlphaTims: Indexing unprocessed trapped ion mobility spectrometry - time of flight data for fast and easy accession and visualization
High resolution mass spectrometry-based proteomics generates large amounts of data, even in the standard liquid chromatography (LC) – tandem mass spectrometry configuration. Adding an ion mobility dimension vastly increases the acquired data volume, challenging both analytical processing pipe...
ORGANISM(S): Homo sapiens (Human) 
2021-07-30 | PXD027359 | Pride
Software. Time of flight Ion mobility spectrometry Data indexing Mass spectrometry Data visualization 
ProteomicsCapillary Zone Electrophoresis-High Field Asymmetric Ion Mobility Spectrometry-Tandem Mass Spectrometry for Top-down Characterization of Histone Proteoforms
Characterization of histone proteoforms with various post-translational modifications (PTMs) is critical for a better understanding of functions of histone proteoforms in epigenetic control of gene expression. Mass spectrometry (MS)-based top-down proteomics (TDP) is a valuable approach for delineat...
ORGANISM(S): Bos taurus (Bovine) 
2023-12-07 | PXD041357 | Pride
Histone Top-down proteomics High-field asymmetric waveform ion mobility spectrometry Post-translational modification Capillary zone electrophoresis 
ProteomicsAutomated 16plex plasma proteomics with real-time search and ion mobility mass spectrometry enables large scale profiling in naked mole-rats and mice.
Performing large-scale plasma proteome profiling is challenging due to limitations imposed by lengthy preparation and instrument time. We present a fully Automated Multiplexed Proteome Profiling Platform (AutoMP3) using the Hamilton VantageTM liquid handling robot capable of preparing hundreds to t...
ORGANISM(S): Mus musculus (Mouse) Heterocephalus glaber 
2021-02-04 | PXD022891 | Pride
Mouse and naked-mole rat plasma 
UnknownCarbohydrate structure characterization by tandem ion mobility mass spectrometry (IMMS)2.
Not available
S-EPMC3633474 | biostudies-literature
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