Sort   by:  
 Page size 
GenomicsEssential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-speci...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-64137 | biostudies-arrayexpress
ProteomicsGlobal ion suppression limits the potential of mass spectrometry based phosphoproteomics
Mass spectrometry-based proteomics has become the method of choice to pinpoint and monitor thousands of post-translational modifications, predominately phosphorylation sites, in cellular signaling studies. Critical for achieving this analytical depth is the enrichment for phosphorylated peptides pri...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD007528 | Pride
Macrophages Tmt Phosphoproteomics Infection Ion supression Lc-ms/ms 
TranscriptomicsRDA-seq (Next generation sequencing of Representational Difference Analysis products) of triticale leaves
RNA from triticale leaves in two varieties (HEWO, MAGNAT) in two growth phases (vegetative, generative) and grown under two cultivation conditions (drought, control) were used to Representational Difference Analysis (cDNA-RDA). Leaves under drought stress used as testers while the leaves grown in co...
ORGANISM(S): x Triticosecale sp. 
2025-08-31 | E-MTAB-15187 | biostudies-arrayexpress
GenomicsSupression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic spo11 allele
Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA bin...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
TranscriptomicsSignatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program
Heirarchical development of B-cells involves the induction and supression of large sets of genes that provide the basis for differentiation and, ultimately, antibody production. We used microarrays to define comprehensive differentiation state-specific transcriptional signatures in order to gain ins...
ORGANISM(S): Mus musculus 
2011-02-14 | E-GEOD-26408 | biostudies-arrayexpress
ProteomicsdHF proteomic following EGb treatment
We have previously shown that standardized extracts of Ginkgo biloba (EGb) modulate fear memory formation, which is associated with CREB-1 (mRNA and protein) upregulation in the dorsal hippocampal formation (dHF), in a dose-dependent manner. Here, we employed proteomic analysis to investigate EGb ef...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-07 | PXD009894 | Pride
Dhf Ginkgo biloba Conditioned lick supression 
ProteomicsA Covalent PFKL Activator Suppresses Tumor Growth
Glycolysis fuels vital cellular functions and its dysregulation is implicated in cancer, neurodegeneration, antibiotic resistance and diabetes. The glycolytic dependency of cancer, known as the Warburg effect, presents a key vulnerability for developing targeted anticancer agents but remains challen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-18 | PXD078921 | Pride
Pfkl Edc Covalent activator Tumor supression Glycolysis 
TranscriptomicsPredator induced gene expression in tadpoles
Tadpoles of the anuran species Rana pirica can undergo predator-specific morphological responses. Exposure to a predation threat by larvae of the salamander Hynobius retardatus results in formation of a bulgy body (bulgy morph) with a higher tail. The tadpoles revert to a normal phenotype upon remov...
ORGANISM(S): Rana pirica 
2009-06-15 | E-GEOD-12005 | biostudies-arrayexpress
TranscriptomicsGene expression dynamics in Beijerinckiaceae bacterium RH AL1 in response to different lanthanum compounds and different lanthanide-containing minerals
We investigated lanthanide (Ln) utilization in Beijerinckiaceae bacterium RH AL1, which requires light Lns (La–Nd) for methanol oxidation. The strain was grown with methanol as the carbon and energy source and with Ln sources including natural minerals (apatite, bastnäsite, gadolinite, loparite, mon...
ORGANISM(S): Beijerinckiaceae bacterium 
2026-02-01 | E-MTAB-15640 | biostudies-arrayexpress
Sort   by:  
 Page size