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ProteomicsCharacterization of Citrullination Sites in Neutrophils and Mast Cells Activated by Ionomycin via Integration of Mass Spectrometry and Machine Learning
Citrullination is an important post-translational modification implicated in many diseases including rheumatoid arthritis (RA), Alzheimer's disease and cancer. Neutrophil and mast cells have different protein-arginine deiminases expression profile and ionomycin induced activation make them the ideal...
ORGANISM(S): Homo sapiens (Human) 
2022-01-12 | PXD023131 | Pride
Citrullination Mass spectrometry Mast cells Neutrophils 
TranscriptomicsEffects of ionomycin (final concentration of 2 µM) and BAPTA/AM (final concentration of 6 µM) on the RO82 W-1 human thyroid cell line
The goal of this study was to identifiy cellular pathways modified by calcium storing in cells presenting a glycolytic metabolism and a poor mitochondrial biogenesis. Keywords: calcium stress response in RO82 W-1 cells In duplicate, cells treated with ionomycin or BAPTA/AM during 96h compared to eq...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-26237 | biostudies-arrayexpress
GenomicsIonomycin suppresses tumor cell growth by disrupting mitochondrial transcription
Ionomycin suppresses tumor cell growth by disrupting mitochondrial transcription
PRJNA1336075 | ENA
ProteomicsInvestigating Neutrophil Responses to Stimuli: Comparative Analysis of reactive species- dependent and independent mechanisms
Neutrophils play a critical role in immune response, using mechanisms as degranulation, and release of neutrophil extracellular traps (NETs) to combat pathogens. NETs are web-like structures composed of chromatin and microbicidal proteins, released by neutrophils in response to many different stimul...
ORGANISM(S): Homo sapiens (Human) 
2025-03-03 | PXD057968 | Pride
Degranulation Neutrophil extracellular traps Ionomycin Nadph oxidase activation Pma 
GenomicsEffect of PMA/Ionomycin mediated T cell activation on Jurkat Tat gene expression
Effect of PMA/Ionomycin mediated T cell activation on Jurkat Tat gene expression
PRJNA916493 | ENA
TranscriptomicsJurkat T cell gene expression with IKKe gene knockdown and PMA and ionomycin stimulation
We used microarray to monitor the differentially expresed genes during Jurkat T cell activaiton. Jurkat T cells with control shRNA or IKKe shRNA were treated with solvent or PMA and ionomycin for 3 h, and then RNA was extracted and applied to microarray analysis
ORGANISM(S): Homo sapiens 
2016-03-11 | E-GEOD-79074 | biostudies-arrayexpress
UnknownEffects of ionomycin on egg activation and early development in starfish.
Not available
S-EPMC3377674 | biostudies-literature
UnknownTyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release.
Not available
S-EPMC3981813 | biostudies-literature
TranscriptomicsIonomycin suppresses tumor cell growth by disrupting mitochondrial transcription
Mitochondrial genome transcription is essential for sustaining oxidative phosphorylation (OXPHOS), a key energy source for tumor cell survival and growth. Recent studies have identified allosteric inhibitors of the mitochondrial RNA polymerase (POLRMT), such as IMT1 and IMT1B, as potential anticance...
ORGANISM(S): Homo sapiens 
2026-09-09 | GSE309432 | GEO
GenomicsMicroarray analysis of naïve bone marrow derived mast cells (BMMCs) and BMMCs 4hr post ionomycin activation
Microarray analysis of naïve bone marrow derived mast cells (BMMCs) and BMMCs 4hr post ionomycin activation
PRJNA854268 | ENA
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