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ProteomicsRegulation of Cl- signaling and ion transport by IRBIT-mediated recruitment of multiple kinases and phosphatases
IRBIT is a multifunctional protein that controls the activity of IP3 receptors and the transporters NBCe1-B, CFTR and Slc26a6, by an unknown mechanism. IRBIT interacts with the NBCe1-B N terminus autoinhibitory domain (AID), exposing two cryptic Cl- sensing GXXXP sites to confer regulation of NBCe1-...
ORGANISM(S): Homo sapiens (Human) 
2020-03-04 | PXD010598 | Pride
Proteomics Irbit Ion channel Phosphorylation 
GenomicsGene expression profiling of IRBIT mutant flies
Gene expression profiling of IRBIT mutant flies
PRJNA432208 | ENA
UnknownSplicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins.
Not available
S-EPMC5393198 | biostudies-literature
TranscriptomicsGene expression profiling of IRBIT mutant flies
In order to understand the biological role of Drosophila IRBIT, we generated null mutant fruitflies. We performed Illumina platform-based RNA-Seq analysis to investigate transcriptional consequences of the mutation using fly midguts as well as whole animals.
ORGANISM(S): Drosophila melanogaster 
2020-02-01 | GSE109862 | GEO
UnknownMultiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL.
Not available
S-EPMC8403746 | biostudies-literature
UnknownBoth IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2.
Not available
S-EPMC7966362 | biostudies-literature
UnknownProtective Role of IRBIT on Sodium Bicarbonate Cotransporter-n1 for Migratory Cancer Cells.
Not available
S-EPMC7558343 | biostudies-literature
UnknownIRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis.
Not available
S-EPMC7068126 | biostudies-literature
UnknownIRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
Not available
S-EPMC3049373 | biostudies-literature
UnknownProtein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor.
Not available
S-EPMC2049018 | biostudies-literature
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