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MetabolomicsAromatic amino acids metabolism shapes autophagy mediated adaptation to iron deprivation in glioma

GBM displays profound iron dependence and metabolic plasticity, yet how iron deprivation interfaces with stress-response pathways and amino acid metabolism in glioma remains incompletely understood. DFO, an iron chelator and hypoxia mimetic, is widely used experimentally, but the integration of a...

2026-08-20 | MTBLS15394 | MetaboLights
Models,MultiomicsIron acquisition and oxidative stress response in aspergillus fumigatus.
Aspergillus fumigatus is a ubiquitous airborne fungal pathogen that presents a life-threatening health risk to individuals with weakened immune systems. A. fumigatus pathogenicity depends on its ability to acquire iron from the host and to resist host-generated oxidative stress. Gaining a deeper und...
7926 | Cell Collective
TranscriptomicsRole of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence...
ORGANISM(S): Mycobacterium tuberculosis 
2007-08-08 | E-GEOD-8732 | biostudies-arrayexpress
TranscriptomicsIron (Fe) deficiency in Citrus
Transcription profiling of citrus rootstock Poncirus trifoliata (L.) Raf. Keywords: Abiotic stress (Iron chlorosis) Total RNA from four replicates for each sample category (Poncirus trifoliata (L.) Raf watered for 60 days with 18 uM Fe-EDDHA or without Fe-EDDHA) were generated and compared.
ORGANISM(S): Poncirus trifoliata 
2010-05-19 | E-GEOD-17255 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat duodenal samples at different developmental stages and the effects of iron-deficiency
The effect of iron-deficiency on duodenal gene expression was investigated in rats at different developmental stages.
ORGANISM(S): Rattus norvegicus 
2007-09-15 | E-GEOD-1892 | biostudies-arrayexpress
MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
TranscriptomicsTranscription profiling of Mycobacterium tuberculosis wild type, ideR mutant and ideR complemented mutants strains grown in iron-sufficient or iron-deficient media
The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin repressor) family. In the presence of iron, it binds to a specific DNA sequence in the promoter regions of the genes that it regulates, thus controlling their transcription. In this study, we provide evidence...
ORGANISM(S): Mycobacterium tuberculosis 
2007-09-12 | E-TABM-317 | biostudies-arrayexpress
MetabolomicsOPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular organelles play pivotal roles in the regulation of ferroptosis, but the mechanisms underlying the contributions of the mitochond...

2025-07-14 | MTBLS10544 | MetaboLights
ProteomicsSurviving oxidative stress under iron starvation: an important lesson eminently learned by Aspergillus fumigatus in the human body
Aspergillus fumigatus has to cope with a combination of several stress types after colonisng the human body, and the interplay between the different stress responses can significantly influence the survival of this human pathogen during the invasion of the host organism. In this study, we examined h...
ORGANISM(S): Aspergillus fumigatus Af293 
2018-05-16 | PXD006250 | Pride
Proteomics Iron starvation Lc-ms Stress response Oxidative stress Aspergillus fumigatus Tandem mass tags 
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
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