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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
MetabolomicsOral Engineered Microalgae- Biosystem Targeting Intestinal Villi for Irritable Bowel Syndrome
Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disorder associated with dysregulation of the gut-brain axis. Current treatment approaches often lack long-term efficacy and target specificity, and there are no drugs or formulations specifically targeting this disease. Owing to chronic a...
2025-07-18 | MTBLS12537 | MetaboLights
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
MetabolomicsPrediction of irritable bowel syndrome by integrating urine metabolites and gut microbiota

Abstract

Background

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent abdominal pain and altered bowel habits. While gut microbiota alterations and metabolic disturbances have been implicated in IBS, t...

2025-07-17 | MTBLS12737 | MetaboLights
TranscriptomicsTranscription profiling of sigmoid colon mucosal biopsies from irritable bowel syndrome patients and healthy control subjects
Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gastrointestinal tract characterized by abdominal pain, bloating, and disturbed bowel function. Here we report on the analysis of microarray expression profiles of sigmoid colon mucosal biopsies from IBS patients and healthy contro...
ORGANISM(S): Homo sapiens 
2007-11-24 | E-TABM-176 | biostudies-arrayexpress
MetabolomicsCognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement
Not available
ORGANISM(S): Homo sapiens 
ST001940 | MetabolomicsWorkbench
TranscriptomicsGene expression analysis of rectal mucosa in chronic irritable bowel syndrome (IBS) compared to healthy volunteers (HV)
An investigation of gene expression changes in rectal biopsies from donors with IBS compared to controls to begin to understand this complex syndrome. To further investigate differences between IBS groups (constipation and diarrhoea predominant) (part1) and how IBS relates to bacterial infection (pa...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-36701 | biostudies-arrayexpress
ProteomicsColonic proteome signature in immunoproteasome-deficient stressed mice and its relevance for irritable bowel syndrome
A role for immunoproteasome in the regulation of intestinal permeability has been previously suggested both in mice during water avoidance stress (WAS) and in patients with irritable bowel syndrome (IBS). We thus aimed (i) to evaluate the colonic proteome in wild-type (wt) and β2i immunoproteasome s...
ORGANISM(S): Mus musculus (Mouse) 
2018-12-05 | PXD011199 | Pride
Colonic proteome  immunoproteasome  irritable bowel syndrome  water avoidance stress. 
ProteomicsProteomic Analysis of rattus norvegicus colonic mucosa following acupuncture treatment for irritable bowel syndrome with diarrhea by label-free LC–MS/MS
To investigate the molecular pathological mechanisms of irritable bowel syndrome with diarrhea (IBS-D) and elucidate the effects of acupuncture on IBS-D colonic mucosa protein abundance in rats, a label-free high-throughput liquid chromatography-tandem mass spectrometry (LC-MS)-based proteomics anal...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-14 | PXD025558 | Pride
Lc-msms Colonic mucosa Rat Acupuncture 
MetabolomicsUPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis
Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...
2021-10-18 | MTBLS1183 | MetaboLights
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