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MetabolomicsCore Functional Nodes and Sex-Specific Pathways in Human Ischemic and Dilated Cardiomyopathy
Not available
ORGANISM(S): Homo sapiens 
ST001364 | MetabolomicsWorkbench
TranscriptomicsMolecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy: left ventricle DCM
We wanted to see whether the set of affected genes in ischemic cardiomyopathy (ICM) is the same or different as compared to dilated cardiomyopathy (DCM). To find this out, we placed the single DCM sample on the same microarray slide with the ICM samples. Analysis of microarray data with ICM samples ...
ORGANISM(S): Homo sapiens 
2010-06-17 | E-GEOD-17530 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hearts exhibiting ischemic and nonischemic cardiomyopathy
Pre-LVAD and explanted ischemic and nonischemic cardiomyopathy and nonfailing hearts all normalized with RMA
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-1869 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human heart with heart failure due to ischemic cardiomyopathy or dilated cardiomyopathy
End stage heart failure due to ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) have similar characteristics, enlargement of the ventricles, relatively thin-walled ventricle, which leads to a limited contraction force and blood loading. Nevertheless, the response for present therapeuti...
ORGANISM(S): Homo sapiens 
2007-10-31 | E-CVDE-1 | biostudies-arrayexpress
TranscriptomicsMolecular Remodeling of Ion Channels in Human Atrial and Ventricular Myocytes Associated with Ischemic Cardiomyopathy
Ischemic cardiomyopathy (ICM) leads to congestive heart failure and can cause sudden cardiac death due to arrhythmia. Existing molecular knowledge base of ICM is rudimentary because of lack of specific attribution to cell type and function. This study was designed to investigate cell-specific molecu...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-17294 | biostudies-arrayexpress
ProteomicsInegrative Proteomic Analysis Reveals the Cytaskeleton Regulation and Mtophagy Diference Between ischemicCardiomyopathy and Dilated Cardiomyopathy
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary etiologies of end-stage heart failure. However, there remains a dearth of comprehensive understanding the global perspective and the dynamics of the proteome and phosphoproteome in ICM and DCM, which hinders the profo...
ORGANISM(S): Homo Sapiens 
PXD065145 |
TranscriptomicsRNA-seq analysis of human heart failure
The goal of this study is to compare the transcriptome of heart failure patients (with ischemic or dilated cardiomyopathy) undergoing heart transplantation compared with healthy controls. We analyzed 36 human samples. 13 from ischemic and 13 from dilated human hearts compared with 10 healthy control...
ORGANISM(S): Homo sapiens 
2014-04-28 | E-GEOD-55296 | biostudies-arrayexpress
ProteomicsSarcomeric Proteoform Landscape in Ischemic Cardiomyopathy Defined by Top-down Proteomics
In ischemic cardiomyopathy (ICM), left ventricular systolic dysfunction leads to reduced blood flow and oxygen supply to the heart. Alterations in sarcomeric protein function and expression play prominent roles in the onset and progression of cardiomyopathies; however, the molecular mechanisms under...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD038066 | Pride
Ischemic cardiomyopathy Top-down proteomics Sarcomere Z-disk proteins Myofilament proteins Quantitative proteomics Human heart proteomics 
ProteomicsProteomic analysis of ischemic and dilated cardiomyopathy pre-mortem human hearts
Our understanding of heart failure (HF) has been provided by indirect surrogates, such as post-mortem histology, cardiovascular imaging, and molecular characterisation in vivo and in vitro, rather than directly in pre-mortem human cardiac tissue. Using our heart bank of pre-mortem hearts procured ac...
ORGANISM(S): Homo sapiens (Human) 
2020-05-01 | PXD018678 | Pride
Ischemic cardiomyopathy Myocardium Dilated cardiomyopathy 
TranscriptomicsTranscription profiling of human ischemic cardiomyopathy, idiopathic cardiomyopathy, and nonfailing controls
Left ventricular myocardium was snap-frozen at time of cardiac transplantation from patients with advanced idiopathic or ischemic cardiomyopathy, or at time of harvest from unused donor heart that serve as a nonfailing control. No subjects received mechanical support devices. Experiment Overall Des...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5406 | biostudies-arrayexpress
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