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ProteomicsInduction of the immunoproteasome subunit Lmp7 links proteostasis and immunity in α-synuclein aggregation disorders, part 1
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson’s disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggregat...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-18 | PXD009717 | Pride
Phosphoproteome Immunoproteasome Α-synuclein Proteomoe 
ProteomicsInduction of the immunoproteasome subunit Lmp7 links proteostasis and immunity in α-synuclein aggregation disorders, part 2
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson’s disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggregat...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-18 | PXD009718 | Pride
Proteomics Immunoproteasome Phosphoproteomics Α-synuclein 
ProteomicsInduction of the immunoproteasome subunit Lmp7 links proteostasis and immunity in α-synuclein aggregation disorders
Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson’s disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggregat...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-18 | PXD009647 | Pride
Proteomics Immunoproteasome Phosphoproteomics Α-synuclein 
TranscriptomicsEffects of nitric oxide on Salmonella adapted at pH 4.4
Reactive nitrogen species (RNS) derived from dietary and salivary inorganic nitrates (NO3-) foment innate host defenses associated with the acidity of the stomach. The mechanisms by which these reactive species exert antibiotic activity in the gastric lumen are, however, poorly understood. To iden...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2010-05-26 | E-GEOD-9398 | biostudies-arrayexpress
ProteomicsMitochondrial morphology, bioenergetics and proteomic responses in fatty acid oxidation disorders
Mutations in nuclear genes encoding for mitochondrial proteins very long-chain acyl-CoA dehydrogenase (VLCAD) and trifunctional protein (TFP) cause rare autosomal recessive disorders. Studies in fibroblasts derived from patients with mutations in VLCAD and TFP exhibit mitochondrial defects. To gain ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-04 | PXD024488 | Pride
Proteomics Very longchain acyl-coa dehydrogenase (vlcad) Long-chain fatty acids (lcfa) Trifunctional protein (tfp) Mitochondria Beta-oxidation 
UnknownThe effects of a motorized passive simulated jogging device on descent of the arterial pulse waveform dicrotic notch: A single arm placebo-controlled cross-over trial.
Not available
S-EPMC9350470 | biostudies-literature
UnknownRegional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration.
Not available
S-EPMC3352979 | biostudies-literature
ProteomicsProteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies.
Nitric oxide (NO) is an important signaling molecule in the cardiovascular system. Reduced bioavailability of NO results in debilitated signaling, which contributes to the pathogenesis of cardiometabolic disorders. However, the alterations in signaling under NO deficiency remain mostly unknown. T...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-29 | PXD060084 | Pride
Heart Cgmp signaling Cardiometabolic disorders Nitric oxide 
ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
A causal relationship between mitochondrial metabolic dysfunction and neurodegeneration has been strongly implicated in synucleinopathies, including Parkinson’s disease (PD) and Lewy body dementia (LBD), but the underlying molecular basis is not fully understood. Here, using human induced pluripoten...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036797 | Pride
S-nitrosylation Alpha-synuclein Tca cycle Mitochondrial dysfunction 
UnknownDetection of Free and Protein-Bound ortho-Quinones by Near-Infrared Fluorescence.
Not available
S-EPMC5555314 | biostudies-literature
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