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ProteomicsWhole cell proteomics analysis of Trypanosoma brucei 75kDa invariant surface glycoprotein knockout cells
A superfamily of invariant surface glycoproteins (ISGs) populates the African trypanosome surface, one of which, ISG75, is implicated in uptake of the century-old drug suramin. We disrupted the ISG75 gene locus encoding an array of six ISG75 paralogs on chromosome V by CRISPR/Cas9 knockout. Here we ...
ORGANISM(S): Trypanosoma brucei 
2023-03-11 | PXD031887 | Pride
Xenobiotics Drug metabolism Drug accumulation Trypanosome Crispr/cas9 Invariant surface glycoprotein Suramin 
ProteomicsPulldown of human serum proteins with Trypanosoma brucei Invariant Surface Glycoprotein 75
Subspecies of Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT) in Sub-Saharan Africa. The surface proteome of trypanosome parasites serves a critical function at the host-parasite interface and is essential for immune evasion. Most of the surface area is covered by ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD047614 | Pride
Trypanosome Sleeping sickness Isg75 
UnknownThe History of Anti-Trypanosome Vaccine Development Shows That Highly Immunogenic and Exposed Pathogen-Derived Antigens Are Not Necessarily Good Target Candidates: Enolase and ISG75 as Examples.
Not available
S-EPMC8400590 | biostudies-literature
UnknownUbiquitylation and developmental regulation of invariant surface protein expression in trypanosomes.
Not available
S-EPMC3147413 | biostudies-literature
UnknownThe role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes.
Not available
S-EPMC9896412 | biostudies-literature
UnknownModulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes.
Not available
S-EPMC4619645 | biostudies-literature
UnknownThe RNA helicase DHH1 is central to the correct expression of many developmentally regulated mRNAs in trypanosomes.
Not available
S-EPMC2823576 | biostudies-literature
UnknownExpression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei.
Not available
S-EPMC6996322 | biostudies-literature
UnknownSuramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.
Not available
S-EPMC7294092 | biostudies-literature
UnknownProteomic selection of immunodiagnostic antigens for human African trypanosomiasis and generation of a prototype lateral flow immunodiagnostic device.
Not available
S-EPMC3584999 | biostudies-literature
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