Islets of langerhans

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Unknown (367)
Transcriptomics (198)
Genomics (120)
Proteomics (40)
Models (7)
Metabolomics (4)
Other (2)

Organisms

Mus musculus (129)
Homo sapiens (106)
Schizosaccharomyces pombe (29)
Oryza sativa Indica Group (29)
Sinorhizobium meliloti BL225C (29)
Sus scrofa domesticus (29)
Saccharomyces cerevisiae (29)
Staphylococcus aureus (29)
Rattus norvegicus (29)
Escherichia coli (29)
Entamoeba histolytica (29)
Physcomitrium patens (29)
Methylohalobius crimeensis 10Ki (29)
Homo sapiens (29)
Shigella flexneri (29)
Ctenopharyngodon idella (29)
Danio rerio (29)
Allexis (29)
Shigella (29)
Pseudomonas putida KT2440 (29)
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Meleagris gallopavo (29)
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Xenopus laevis (3)
Canis lupus familiaris (2)
Sus scrofa (2)
synthetic construct (1)
Danio rerio (1)
Rattus rattus (1)

Organisms

Mus musculus (39)
Homo sapiens (12)
synthetic construct (1)
Danio rerio (1)
Rattus norvegicus (1)
Canis lupus familiaris (1)

Repository

biostudies-arrayexpress (165)
ENA (59)
geo (48)
EGA (46)
pride (29)
MassIVE (9)
BioModels (7)
MetaboLights (4)
ExpressionAtlas (2)
jPOST (1)
PanoramaPublic (1)

Tissue

Islet of Langerhans (20)
Pancreatic islet (10)
Pancreas (5)
Cell culture (5)
Pancreatic islet cell (4)
Epithelial cell (2)
Pancreas development (1)
Endocrine pancreas (1)
Pancreatic islet beta cell (1)
Pancreatic delta cell (1)
Pancreatic alpha cell (1)
Type B pancreatic cell (1)
HiPSC cell (1)
Urine (1)
HeLa cell (1)
Primary cell (1)

Disease

Type 2 diabetes mellitus (6)
Type 1 diabetes mellitus (5)
Disease free (4)
Diabetes mellitus (1)
4T1 tumor-bearing (1)
Aggressive insulitis (1)
Mild hyperglycemia (1)
No disease (1)
Normal (1)
Maturity-onset diabetes of the young type 1 (1)
Insulinoma (1)

Technology Type

Mass Spectrometry (29)
Shotgun proteomics (15)
Data-independent acquisition (5)
Bottom-up proteomics (5)
Mass spectrometry assay (3)
Affinity purification coupled with mass spectrometry proteomics (3)
ILLUMINA, Illumina HiSeq 2500 (2)
Illumina HiSeq 2000 (2)
SRM/MRM (2)
Top-down proteomics (2)
Mass spectrometry (1)
All-ion fragmentation (1)
SWATH MS (1)
Data-dependent acquisition (1)

Instrument Platform

Illumina NovaSeq 6000 (9)
Illumina HiSeq 2000 (4)
Orbitrap Fusion Lumos (4)
Q Exactive (3)
Affymetrix Fluidics Station 400 (2)
NextSeq 500 (2)
Affymetrix GeneChip Scanner 3000 (GCS3000) (1)
Illumina Genome Analyzer (1)
Illumina Genome Analyzer IIx (1)
Illumina Genome Analyzer II (1)
Illumina HiSeq 1000 (1)
Illumina HiSeq 2500 (1)
Synapt MS (1)
LTQ Orbitrap Velos (1)
Orbitrap Eclipse (1)
Q Exactive HF (1)
Agilent 6550 iFunnel Accurate-Mass UHPLC-QTOFMSMS (negative mode) (1)
Agilent 6550 iFunnel Accurate-Mass UHPLC-QTOFMSMS (positive mode) (1)
LECO Pegasus III, GCTOFMS (1)
Liquid Chromatography MS - alternating - reverse-phase (1)
Liquid Chromatography MS - alternating - reverse phase (1)
Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2014 (29)
2023 (20)
2013 (20)
2016 (19)
2010 (19)
2022 (15)
2012 (15)
2011 (15)
2025 (14)
2015 (14)
2007 (12)
2024 (11)
2021 (11)
2008 (10)
2026 (8)
2020 (7)
2019 (7)
2006 (5)
2018 (5)
2009 (4)
2005 (2)
2017 (2)
2003 (1)

UNIPROT ID/AC

P14618 (2)
P17858 (2)
P35557 (2)
O60825 (2)
Q16875 (2)
P16118 (2)
Q16877 (2)
P05062 (2)
P09972 (2)
P04075 (2)
P00338 (2)
P07195 (2)
Q9BYZ2 (2)
P07864 (2)
P30613 (2)
P06744 (2)
P09104 (2)
P13929 (2)
O00757 (2)
P08237 (2)
O14556 (2)
P00558 (2)
P07205 (2)
Q9NQ88 (1)
Q9UJ73 (1)
Q9UMQ9 (1)
Q9UMR0 (1)
Q01813 (1)
Q16850 (1)
Q9BQG2 (1)

CHEBI ID

CHEBI:16761 (4)
CHEBI:4167 (3)
CHEBI:58579 (2)
CHEBI:16651 (2)
CHEBI:58289 (2)
CHEBI:58272 (2)
CHEBI:57604 (2)
CHEBI:58027 (2)
CHEBI:57642 (2)
CHEBI:57299 (2)
CHEBI:30616 (2)
CHEBI:61548 (2)
CHEBI:57540 (2)
CHEBI:57945 (2)
CHEBI:43474 (2)
CHEBI:456216 (2)
CHEBI:15377 (2)
CHEBI:29108 (2)
CHEBI:14314 (2)
CHEBI:15361 (2)
CHEBI:16905 (2)
CHEBI:15422 (2)
CHEBI:18021 (2)
CHEBI:3554 (1)
CHEBI:3338 (1)
CHEBI:3966 (1)
CHEBI:3312 (1)
CHEBI:3313 (1)
CHEBI:3628 (1)
CHEBI:3454 (1)

Metabolite Name

D-glucopyranuronic acid (1)
(Z)-icos-11-enoic acid (1)
D-fructofuranose 6-phosphate (1)
Cellotriose (1)
Aldehydo-L-arabinose (1)
Beta-lactose (1)
Aldehydo-D-ribose 5-phosphate (1)
D-glucopyranose 6-phosphate (1)
N(pros)-methyl-L-histidine (1)
L-alpha-aminobutyric acid (1)
L-rhamnopyranose (1)
1,5-anhydro-D-glucitol (1)
Glycylglycine (1)
All-cis-docosa-4,7,10,13,16,19-hexaenoic acid (1)
Maltitol (1)
¦Ã-Glu-Lys (1)
Cyclo(leu-phe) (1)
Cis-Citral (1)
[(2R)-3-Hexadecoxy-2-hydroperoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate (1)
Trp-Ala-Asp (1)
Triphenyl-phosphate (1)
Trimethylamine-N-Oxide (1)
Triethyl-phosphate (1)
Thiamine-Monophosphate (1)
Tetraethylene-glycol (1)
Shinorine (1)
Ser-Phe-Ala (1)
ST-638 (1)
SPH(d18:2) (1)
S1P(d18:2) (1)

First Public Date

2023 (13)
2021 (10)
2014 (9)
2025 (5)
2020 (4)
2019 (4)
2024 (3)
2022 (3)
2016 (3)
2026 (2)
2018 (1)
2017 (1)
2013 (1)

Modelling Approach

Ordinary differential equation model (4)
Agent-based model (1)
Differential equation model (1)

Lab affiliation

Medical Bioanalytics Institute for Ophthalmic Research Eberhard-Karls University of Tuebingen (2)
Catholic University of Leuven, Laboratory of Clinical and Experimental Endocrinology, Leuven, Belgium (1)
Department of Biomedical Science, University of Copenhagen, Denmark (1)
Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland (1)
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. Campusvej 55, Odense 5230 Denmark (1)
Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Germany (1)
Department of Laboratory Medicine, Sahlgrenska academy, University of Gothenburg, Gothenburg, Sweden (1)
Paul & Ellen Lacy Professor of Pathology & Immunology Division of Immunobiology Washington University in St. Louis St. Louis, MO 63110 USA (1)
Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy (1)
Protein research group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark. (1)
1Ruijin Yangtze River Delta Health Institute, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (1)
School of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney (1)
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States (1)
Joslin Diabetes Center/Harvard Medical School (1)
Institute of Diabetes and Regeneration Research, Helmholtz Center Munich, Neuherberg, Germany; School of Medicine, Technical University of Munich, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany. (1)
Department of Biotechnology St Aloysius (Deemed to be University) Mangalore – 575 003, Karnataka, India. (1)
Heart Institute, Cedars-Sinai Medical Center (1)
Department of Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences University of Colorado (1)
structural biology and bioinformatics (1)
Director Dept. Proteomics and Signal Transduction Max Planck Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried (near Munich) Germany (1)
Wellcome Trust MRC Institute of Metabolic Science (1)
Department of Pharmaceutical Sciences, University of Colorado - Anschutz Medical Campus, Aurora, CO, USA (1)
Department of Pharmaceutical Biosciences, Uppsala University (1)
Charles Perkins Centre and School of Medical Sciences, University of Sydney, Sydney, Australia. (1)
Biological Sciences Division, Pacific Northwest National Laboratory (1)
School of Pharmacy, University of Wisconsin-Madison (1)
Department of Clinical Science, Faculty of Medicine, University of Bergen, Norway (1)
Department of Clinical Science, University of Bergen, Bergen, Norway Department of Pediatrics, Haukeland University Hospital, Bergen, Norway (1)

IsPrivate

False (7)

Model Flag

Non Kinetic (1)

Modification

Not available (1)

Study type

Transcription profiling by array (96)
RNA-seq of coding RNA (38)
ChIP-seq (7)
ChIP-chip by tiling array (3)
Methylation profiling by array (3)
Methylation profiling by high throughput sequencing (3)
RNA-seq of non coding RNA (3)
Unknown experiment type (2)
Other (2)
MicroRNA profiling by array (2)
RNA-seq of coding RNA from single cells (2)
FAIRE-seq (1)
Transcription profiling by SAGE (1)
Animal - One-color microarray (1)
Animal - High-throughput sequencing (1)

Release Date

2022 (49)
2021 (47)
2014 (45)
2013 (34)
2016 (32)
2018 (31)
2010 (28)
2025 (28)
2015 (28)
2023 (26)
2011 (26)
2020 (24)
2019 (20)
2012 (19)
2024 (18)
2017 (18)
2008 (15)
2007 (14)
2009 (10)
2006 (9)
2005 (3)
2026 (2)
2003 (2)
2000 (2)
2002 (1)
2001 (1)

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Deamidation in human islets of Langerhans

The β-cell plays a central role in the pathogenesis of T1D by neoantigen formation due to the generation of post-translational modifications, such as deamidation, being potential triggers for breaking immune tolerance. We report the detection by LC-MS/MS of 16 novel Gln and 27 novel Asn deamidations...

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD038758 | Pride

The human pancreatic islet transcriptome: impact of pro-inflammatory cytokines

We have used RNA-seq to identify transcripts, including splice variants, expressed in human islets of Langerhans under control condition or following exposure to the pro-inflammatory cytokines interleukin-1β (IL-1β) and interferon-γ (IFN-γ). A total of 29,776 transcripts were identified as expressed...

ORGANISM(S): Homo sapiens

2012-03-09 | E-GEOD-35296 | biostudies-arrayexpress

Microarray analysis of islets of Langerhans from 3 week-old NOD, NOR and C57Bl/6 mice

The aim of this study was to investigate which intrinsic differences are present in the islets of Langerhans from diabetes-prone non-obese diabetic (NOD) mice before the onset of insulitis.

ORGANISM(S): Mus musculus

2016-11-30 | E-MTAB-5264 | biostudies-arrayexpress

Human islet of Langerhans grown on nanosubstrates LC-MSMS

Intensive efforts are focused on identifying regulators of human pancreatic islet cell growth and maturation to accelerate development of therapies for diabetes. In the present study we evaluate the contribution of the physical properties of the extracellular matrix in supporting long term culture o...

ORGANISM(S): Homo sapiens (Human)

2018-07-11 | PXD007569 | Pride

Human Lc-msms Islet of langerhans Nanosubstrates

DNA methylation profiling of male human pancreatic islets identifies loci for type 2 diabetes

Little is known about the contribution of the epigenome to the pathophysiology of type 2 diabetes (T2D). Here we have used genome-wide DNA methylation profiling to obtain the first comprehensive DNA methylation data set for human T2D pancreatic islets. Therefore, we analyzed the methylation profile ...

ORGANISM(S): Homo sapiens

2012-04-22 | E-GEOD-21232 | biostudies-arrayexpress

Well-plate uFASP for proteomic analysis of single pancreatic islets

Filter-aided sample preparation (FASP) is widely used in bottom-up proteomics for tryptic digestion. However, the sample recovery yield of this method is limited by the amount of starting material. While ~100 ng of digested protein sample is sufficient for thorough protein identification, proteomic ...

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2022-04-01 | PXD029039 | Pride

Fasp Islets of langerhans Method development

Adiponectin improves local lipid metabolism in regenerating pancreatic islets after β-cell ablation

Pathways that stimulate β-cell regeneration remain of great clinical interest, yet effective therapeutic avenues that promote survival or reconstitution of β-cell mass remain elusive. Utilizing a mouse model with inducible β-cell apoptosis followed by adiponectin-mediated regeneration, we aimed to i...

ORGANISM(S): Mus musculus

2015-01-09 | E-GEOD-64787 | biostudies-arrayexpress

Identification of HIPs in the islets of mice and non-diabetic human donors

Hybrid insulin peptides (HIPs) result from the linkage of an insulin C-peptide fragment and another peptide via a traditional peptide bond to generate a sequence that is not encoded in the genome. Here, we sought to identify HIPs naturally present in the pancreatic islets of non-obese diabetic (NOD)...

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2019-01-07 | PXD011606 | Pride

Hybrid insulin peptides (hips) Pancreatic islets

The Pdx1 Cistrome of Pancreatic Islets

We performed global location analysis of Pdx1 occupancy in mouse and human islets.

ORGANISM(S): Mus musculus

2012-05-23 | E-MTAB-1143 | biostudies-arrayexpress

Genome-wide DNA methylation in normal and IUGR pancreatic islets

Intrauterine growth restriction (IUGR) increases susceptibility to age-related diseases including type 2 diabetes (T2DM), and is associated with permanent and progressive changes in gene expression and epigenetic regulation. We studied cytosine methylation throughout the genome in pancreatic islets...

ORGANISM(S): Rattus norvegicus

2010-06-24 | E-GEOD-16839 | biostudies-arrayexpress

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