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ProteomicsHypoxia-induced proteomic remodeling of human mammary cancer associated fibroblast - siRNA NCBP2-AS2
Intratumoral hypoxia causes the formation of dysfunctional blood vessels which contribute to tumor metastasis. Blood vessels are embedded in the tumor stroma where cancer-associated fibroblasts (CAFs) constitute the most prominent cellular component. We found that hypoxic human mammary CAFs promote ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD006539 | Pride
Cancer Angiogenesis Hypoxia Silac Caf Proteome Secretome 
ProteomicsHypoxia-induced proteomic remodeling of human mammary cancer associated fibroblast
Intratumoral hypoxia causes the formation of dysfunctional blood vessels which contribute to tumor metastasis. Blood vessels are embedded in the tumor stroma where cancer-associated fibroblasts (CAFs) constitute the most prominent cellular component. We found that hypoxic human mammary CAFs promote ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD006535 | Pride
Breast cancer  caf  proteomics  secretome  hypoxia  angiogenesis 
ProteomicsTumor matrix stiffness induces CCN1/CYR61 upregulation of N-Cadherin to promote cancer cell trans-endothelial migration and metastasis
Tumor progression is often accompanied with increased extracellular matrix stiffness, but how this affects endothelial cells (ECs) is largely unknown. We used mass spectrometry to analyse the proteomic changes of primary human ECs cultured on physiological or tumor stiffness and found that CCN1/CYR6...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD003316 | Pride
Stiffness  protome  silac  ccn1  matrigel  huvec  tumour  vasculature 
ProteomicsProteome and secretome of human mammary normal fibroblasts and CAF
The secretome of cancer and stromal cells generates a microenvironment which contributes to tumour cell invasion and angiogenesis. Here, we compare the secretome of human mammary normal fibroblasts and cancer-associated fibroblasts (CAF). We discover that the chloride intracellular channel protein ...
ORGANISM(S): Homo sapiens (Human) 
2016-12-13 | PXD002444 | Pride
Tgm2 Caf Cysteine oxidation Fibroblasts Clic3 Lc-ms/ms 
UnknownThe oral microbiome profile of Pakistani infants characterized by 16S rRNA amplicon sequencing.
Not available
S-EPMC12855591 | biostudies-literature
UnknownPopulation genomic analyses reveal high diversity, recombination and nosocomial transmission among Candida glabrata (Nakaseomyces glabrata) isolates causing invasive infections.
Not available
S-EPMC10868614 | biostudies-literature
ProteomicsThe ARFGEF IQSEC1 is a targetable scaffold controlling collective cell invasion.
The signalling pathways underpinning cell growth and migration share overlapping components but what determines whether cells grow or move, when exposed to the same extrinsic signal, is unclear. We identify that in epithelial cancer cells cultured in extracellular matrix (ECM) these molecular functi...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD013810 | Pride
Epithelial cancer cells Prostate cancer Iqsec1 Growth and migration Gfp trap 
ProteomicsFam49/CYRI interacts with Rac1 and locally suppresses protrusions
Actin-based protrusions driving cell migration are reinforced through positive feedback, but it is unclear how the cell restricts the eventual size of protrusions, or limits positive signals to allow them to split or retract. We have identified an evolutionarily conserved regulator of the protrusio...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2018-10-08 | PXD010460 | Pride
Lamellipodia Cyfip-related rac interactor Dictiostelium discoideus Gfp-trap with formaldehyde crosslinking Scar/wave complex Cell migration 
UnknownCystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study.
Not available
S-EPMC10807905 | biostudies-literature
UnknownEarly sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.
Not available
S-EPMC7939103 | biostudies-literature
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