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ProteomicsStop trashing your spectra! Use a “Quantify then Identify” pipeline based on machine learning to maximize your isobaric tagging data
Being inspired by metabolomic data processing, we have developed a bioinformatic pipeline that optimizes the processing of mass spectral data obtained from isobaric Tandem Mass Tag (TMT) experiments. Our method focuses on the tandem mass spectral level by first quantifying and then identifying (QtI)...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-05-01 | PXD005206 | Pride
Plasma Isobaric tagging Tmt Human Lc-ms Csf 6-plex Orbitrap 
ProteomicsAn adaptive pipeline to maximize isobaric tagging data in large-scale MS-based proteomics
Isobaric tagging is a method of choice in Mass Spectrometry (MS)-based proteomics for comparing multiple conditions at a time. Despite its multiplexing capabilities, when multiple experiments are merged for comparison in large sample-size studies, some drawbacks appears, due to the presence of missi...
ORGANISM(S): Homo sapiens (Human) 
2018-05-01 | PXD008029 | Pride
Algorithms  bioinformatics  biomarkers  discovery  isobaric tagging  machine learning  protein identification  quantification  tandem mass spectrometry  tandem mass tag 
UnknownIncreased N,N-Dimethyl Leucine Isobaric Tag Multiplexing by a Combined Precursor Isotopic Labeling and Isobaric Tagging Approach.
Not available
S-EPMC6314838 | biostudies-literature
UnknownAutomated Sample Multiplexing by using Combined Precursor Isotopic Labeling and Isobaric Tagging (cPILOT).
Not available
S-EPMC9153850 | biostudies-literature
UnknownStrategies for mass spectrometry-based phosphoproteomics using isobaric tagging.
Not available
S-EPMC8595857 | biostudies-literature
ProteomicsAdditional precursor purification in isobaric mass tagging experiments by traveling wave ion mobility separation (TWIMS).
We investigated if additional peptide purification by traveling wave ion mobility separation (TWIMS) can reduce precursor contamination using a mixture of S. cerevisiae and HeLa proteomes. In accordance with previous reports on FAIMS-Orbitrap instruments, we find that TWIMS provides a remarkable imp...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2014-06-10 | PXD001047 | Pride
Ims Tmt Ion mobility separation Isobaric mass tag Tandem mass tag Travelling wave ion mobility separation Twims 
UnknownIsobaric mass tagging and triple quadrupole mass spectrometry to determine lipid biomarker candidates for Alzheimer's disease.
Not available
S-EPMC6903722 | biostudies-literature
UnknownBoosting Quantification of N-Glycans by an Enhanced Isobaric Multiplex Reagents for Carbonyl-Containing Compound (SUGAR) Tagging Strategy.
Not available
S-EPMC12450061 | biostudies-literature
ProteomicsSimPLIT: Simplified sample preparation for large-scale isobaric tagging proteomics
Large scale proteomic profiling of cell lines can yield valuable insights into the molecular signatures attributed to variable genotypes or induced perturbations. Specifically, the ability to perform deep and rapid proteome analysis of pharmacologically modulated cells could generate drug-protein as...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD031510 | Pride
Tmtpro Imids Celmods Targeted protein degradation Cancer cell lines Isobaric labeling 
ProteomicsSimPLIT: Simplified sample preparation for large-scale isobaric tagging proteomics
Large scale proteomic profiling of cell lines can yield valuable insights into the molecular signatures attributed to variable genotypes or induced perturbations. Specifically, the ability to perform deep and rapid proteome analysis of pharmacologically modulated cells could generate drug-protein as...
ORGANISM(S): Homo sapiens (Human) 
2022-08-03 | PXD034022 | Pride
Imids Tmtpro Celmods Targeted protein degradation Cancer cell lines Isobaric labeling 
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