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MetabolomicsOld mitochondria regulate niche renewal via stem cell metabolism
Cellular metabolism is emerging as a potent regulator of cell fate, raising the possibility that the recently discovered metabolic heterogeneity between newly synthesized and chronologically old organelles may impact stem cell fate in mammalian tissues. The small intestine is maintained by actively ...
2025-04-24 | MTBLS12349 | MetaboLights
MetabolomicsIdentifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
Identifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa.
2026-03-29 | MTBLS14179 | MetaboLights
MetabolomicsIdentifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
Identifying glycolysis in mitochondria as a new perspective on the pathogenesis of retinitis pigmentosa
2026-03-28 | MTBLS14170 | MetaboLights
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsHuman mitochondria hub of small RNAs: Analysis by deep Sequencing
We report here that human mitochondria contain small RNA including microRNA, piRNA, tRNA, rRNA, and RNA repeats. Mitochondria from human cells were purified and RNA isolated. Small RNAs were purified, library generated and analyzed by Illumina Hiseq 2000 system. The sequencing generated 19.5 and 17....
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-32185 | biostudies-arrayexpress
MetabolomicsMitochondrial Transplantation of Brown Adipocytes Interferes with the Metabolism of Tumor Stem Cells and Inhibits the Recurrence of Brain Glioma after Operation

Glioblastoma multiforme (GBM) is highly aggressive, with treatment resistance and recurrence driven by metabolically plastic glioma stem cells (GSCs). Inspired by brown adipose tissue (BAT) thermogenesis, researchers transplanted BAT-derived mitochondria (BA-Mito) into GSCs, reducing stemness mar...

2025-08-27 | MTBLS12901 | MetaboLights
GenomicsmRNA expression in endothelial cells stimulated with isolated mitochondria
mRNA expression in endothelial cells stimulated with isolated mitochondria
PRJNA534320 | ENA
ProteomicsComparative proteomic study on liver lipid droplets and mitochondria from mouse housed in different temperatures
Laboratory mice are standardly housed around 23ºC, setting them under chronic cold stress. Metabolic changes of liver in mice housed under thermoneutral, standard and cold temperatures remain unknown. Here we isolated lipid droplets and mitochondria from their livers for comparative proteomic study ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-07-17 | MSV000084105 | MassIVE
ProteomicsAdaption of oxidative phosphorylation machinery compensates hepatic lipotoxicity in early stages of MAFLD, isolated mitochondria PMID:3543314
Mitochondrial function is an important control variable in the progression of metabolic dysfunction associated fatty liver disease (MAFLD). We hypothesize that organization and function of mitochondrial electron transport chain (ETC) in this pathologic condition is a consequence of shifted substrate...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD032211 | Pride
Mouse Mafld  isolated mitochondria Mitochondrial function 
ProteomicsIsolated Mitochondria from Cold and TN Mice LC MS/MS
: Proteomic Analysis from isolated mitochondria from the brown fat of C57BL6/J mice that were exposed to cold or thermoneutrality for 8 days.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD043251 | Pride
Mitochondria Thermoneutrality Cold Nipsnap1 
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