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MetabolomicsPatA mediates biofilm formation and drugs resistance through regulating the synthesis of glycolipids and lipids in mycobacterium PatA mediates a novel mycolic acid synthesis pathway and regulates biofilm formation in mycobacterium
Glycolipids and lipids are prominent components of bacterial cell wall that play critical roles not only in maintaining the biofilm formation but also in resistance to environmental stress. PatA is an essential membrane associated acyltransferase involved in the biosynthesis of phosphatidyl-myo-inos...
2023-05-22 | MTBLS6758 | MetaboLights
ProteomicsProteomics of Mycobacterium tuberculosis Beijing genotype after acquisition of Isoniazid resistance
This project provides the first characterization of protein differences in clinical isolates of Mtb after acquisition of resistance to isoniazid (INH), one of the most important drug treatment options against TB. This study determines the global protein differences in a clinical isogenic pair of Mtb...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2016-03-14 | PXD002986 | Pride
Isoniazid Tuberculosis Resistance Ltq Proteomics Mycobacterium Beijing Lc-ms/ms 
ProteomicsComprehensive biochemical characterization of Mycobacterium tuberculosis clonal strains after isoniazid resistance
This project describes the isoniazid (INH) resistance acquisition event in Mycobacterium tuberculosis (Mtb) from the proteomics perspective. In this way, an exploration of the protein differences, comparing clonal INH susceptible (INHs) and INHr pairs of Mtb were evaluated. One clonal clinical and o...
ORGANISM(S): Mycobacterium tuberculosis 
2018-06-25 | PXD009549 | Pride
Mycobacterium tuberculosis Isoniazid resistance 
UnknownHigh-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment.
Not available
S-EPMC12096161 | biostudies-literature
ProteomicsProtein profile at different cellular fractions of Mycobacterium tuberculosis strains after exposure to Isoniazid
Out of the 10 million of tuberculosis (TB) cases estimated in the world, around 14% are isoniazid (INH) resistant among new cases and 29% among previously treated cases in the last decade. INH is one of the oldest but also one of the more potent drugs to eliminate Mycobacterium tuberculosis (Mtb), t...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2019-06-17 | PXD007588 | Pride
Cellular fractions Tuberculosis Isoniazid Shotgun proteomics Lc-ms/ms 
GenomicsChemical disarming of isoniazid resistance in Mycobacterium tuberculosis
Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis
PRJNA532912 | ENA
TranscriptomicsAccumulation of inorganic polyphosphate mediates metabolic downshift and antibiotic tolerance in Mycobacterium tuberculosis
The stringent response, involving the regulatory molecules inorganic polyphosphate (poly P) and (p)ppGpp, is believed to mediate Mycobacterium tuberculosis persistence. In this study, we identified a novel exopolyphosphatase responsible for poly P hydrolysis. Using two different poly P-accumulating ...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2015-02-20 | E-GEOD-57868 | biostudies-arrayexpress
UnknownPopulation genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
Not available
S-EPMC1538650 | biostudies-literature
UnknownIsoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations.
Not available
S-EPMC5818527 | biostudies-literature
UnknownEpidemiology of isoniazid resistance mutations and their effect on tuberculosis treatment outcomes.
Not available
S-EPMC3719713 | biostudies-literature
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