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ProteomicsSite-specific Profiling of Lysine Itaconylation via a Thiol-based Probe
Lysine itaconylation is a novel post-translational modification (PTM) that was recently discovered in macrophage proteomes mediated by the immunoregulatory metabolite, itaconate. However, there is currently an absence of comprehensive and high-accuracy analytical methods for the global identificatio...
ORGANISM(S): Mus Musculus Bos Taurus 
2026-04-21 | PXD077428 |
ProteomicsSite-specific Profiling of Lysine Itaconylation via a Thiol-based Probe
Lysine itaconylation is a novel post - translational modification (PTM) that was recently discovered in macrophage proteomes mediated by the immunoregulatory metabolite, itaconate. However, there is currently an absence of comprehensive and high - accuracy analytical methods for the global identific...
ORGANISM(S): Mus Musculus 
2025-08-20 | PXD067524 |
ProteomicsDiscovery of Itaconate-Mediated Lysine Acylation
Itaconate is an important anti-microbial and immunoregulatory metabolite involved in host-pathogen interactions. A key mechanistic action of itaconate is through the covalent modification of cysteine residues via Michael addition, resulting in “itaconation”. However, it is unclear whether itaconate ...
ORGANISM(S): Mus Musculus 
2023-02-28 | PXD040508 |
ProteomicsIRG1 Inflammasome Proteomics Experiments
BMDMs of indicated phenotypes were stimulated with LPS for 24h and analyzed or restimulated with LPS for additional 3h and analyzed. In some experiments 1mM itaconate was added at 4h of LPS first stimulation.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020089 | Pride
Lps Irg1 Bmdm Itaconylation Lcms Proteomics 
ProteomicsSIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice
Proper regulation of inflammatory responses is essential for organismal health. Dysregulation can lead to accelerated development of the diseases of aging and the aging process itself. Here, we identify a novel enzymatic activity of the mitochondrial sirtuin SIRT4 as a lysine deitaconylase that regu...
ORGANISM(S): Mus Musculus (mouse) 
2026-05-13 | PXD063862 | JPOST Repository
ProteomicsItaconate modulates immune responses via inhibition of peroxiredoxins
Itaconate is a natural mild electrophile, able to modify free thiols in proteins upon activation. We submit two datasets investigating peptides modified by itaconate. Experiment001 contains data obtained from endogenous itaconate producing WT or itaconate incompetent Irg1-/- Bone marrow-derived macr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-28 | MSV000093522 | MassIVE
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