Sort   by:  
 Page size 
ProteomicsItch Ubiquitin Ligase Deficiency and B cell LC-MSMS
The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show that Itch directly limits B cell activity. Using LC-MSMS, we profiled and compared the whole cell proteomes of Itch defici...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-12 | PXD014243 | Pride
Itch ubiquitin ligase Lc-msms Tlr9 B cell 
TranscriptomicsGenome-wide mRNA expression profiling for Wild Type and Itch-/- Skin Transcriptomes by RNA sequencing
To test the hypothesis that defects in the termination of inflammatory signaling led to skin inflammation that results in the “Itchy” phenotype, we isolated RNA from the lesional skin of Itch-/- mice and from the skin of wild-type mice and performed genome-wide mRNA expression profiling by RNA seque...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-65686 | biostudies-arrayexpress
TranscriptomicsRNA-seq of splenic B cells derived from WT and Itch cKO mice
We found that the E3 ubiquitin ligase Itch significantly affects early B-cell differentiation. To explore the role of Itch in late B-cell differentiation, we sorted B cells from WT and Itch cKO mice. To explore the effect of Itch deficency on gene expression, we determined mRNA profiles in B cells ...
ORGANISM(S): Mus musculus 
2020-03-01 | E-MTAB-8281 | biostudies-arrayexpress
TranscriptomicsRNA-seq of splenic B cells derived from WT and Itch KO mice
We found that the E3 ubiquitin ligase Itch significantly affects early B-cell differentiation. To explore the role of Itch in late B-cell differentiation, we sorted B cells from WT and Itch KO mice. To explore the effect of Itch deficency on gene expression, we determined mRNA profiles in B cells f...
ORGANISM(S): Mus musculus 
2020-03-01 | E-MTAB-8273 | biostudies-arrayexpress
ProteomicsThe Ubiquitin Ligase Itch Skews Light Zone Selection in Germinal Centers
Ig diversification occurs in peripheral lymphoid organs after establishment of central tolerance during B cell development. In germinal centers (GCs), somatic hypermutation of Ig genes occurs in dark zones, followed by selection of mutated clones in light zones (LZs). This generates high-affinity Ig...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-12 | PXD040978 | Pride
B-cell Germinal center Autoimmunity Ubiquitin ligase 
ProteomicsItch attenuates CD4 T cell proliferation in mice by limiting WBP2 protein stability
To mount an anti-pathogen response, CD4 T cells must undergo rapid cell proliferation. However, poorly controlled expansion can result in diseases such as autoimmunity. One important regulator of T cell activity is the E3 ubiquitin ligase Itch. Itch deficient patients suffer from extensive autoinfla...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-07 | PXD019272 | Pride
Proliferation E3 ubiquitin ligase Cell cycle Autoinflammation 
UnknownPhosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase.
Not available
S-EPMC5777250 | biostudies-literature
UnknownATM kinase activity modulates ITCH E3-ubiquitin ligase activity.
Not available
S-EPMC3938399 | biostudies-literature
UnknownHuman ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.
Not available
S-EPMC2833372 | biostudies-literature
UnknownItch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected].
Not available
S-EPMC3064387 | biostudies-literature
Sort   by:  
 Page size