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ProteomicsComprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain
Using a high-end mass spectrometry, we screened phosphoproteins and phosphopeptides in four types of Alzheimer's disease (AD) mouse models and human AD postmortem brains. We identified commonly changed phosphoproteins in multiple models and also determined phosphoproteins related to initiation of Ab...
ORGANISM(S): Mus musculus (Mouse) 
2014-09-10 | PXD001292 | Pride
Pkcs Preclinical alzheimer's disease Kinases Signaling network Phosphoproteome Camks 
TranscriptomicsGene expression signatures for human iPS cell lines
The reprogramming of human fibroblasts to generate induced pluripotent stem cells (hiPSCs) has been achieved through the expression of only a few exotic factors1-8, which is morphologically and molecularly verified in outer cellular states by characteristic markers, due to the remodeling of the soma...
ORGANISM(S): Homo sapiens 
2011-03-07 | E-GEOD-20750 | biostudies-arrayexpress
ProteomicsHMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, which prevents Ku70-DNA interaction, in human AD postmor...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028089 | Pride
Hmgb1 Ku70 Phosphorylation Alzheimer's disease 
ProteomicsNRDC-IP
IP-MS analysis against endogenous NRDC using megakaryocyte cell lysates.
ORGANISM(S): Homo Sapiens (human) 
2018-07-19 | PXD009739 | JPOST Repository
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