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ProteomicsMBEC4 cells with low-Arginine conditions
Amino acid transporters are expressed in the brain capillary endothelial cells, which form the blood-brain barrier, and their expression levels change during the neonatal period. This study aimed to investigate the molecular mechanisms regulating the amino acid transporter levels in mouse brain capi...
ORGANISM(S): Mus Musculus (mouse) 
2025-04-11 | PXD054477 | JPOST Repository
ProteomicsDigestion time course of human liver plasma membrane
The selection of signature peptides is critical for reliable peptide quantification. The purpose of this study was to comprehensively assess the digestion efficiency and stability of tryptic peptides and to identify optimal signature peptides for human hepatic transporters and membrane marker protei...
ORGANISM(S): Homo Sapiens (human) 
2022-10-12 | PXD034402 | JPOST Repository
ProteomicsMouse liver and kidney proteome with antibiotics treatment
Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-meta...
ORGANISM(S): Mus Musculus (mouse) 
2018-01-01 | PXD008237 | JPOST Repository
ProteomicsProteomic study of the mice treated with antibiotics
Antibiotic administration affects pharmacokinetics through changes in the intestinal microbiota, and bile acids are involved in this regulation. The purpose of the present study was to clarify the effect of different periods of antibiotic administration on the expression of pharmacokinetic-related p...
ORGANISM(S): Mus Musculus (mouse) 
2023-07-12 | PXD037296 | JPOST Repository
ProteomicsProteome analysis of adult mouse brain capillaries
Isolated brain capillaries are essential for analyzing the changes of protein expressions at the blood-brain barrier (BBB) under pathological conditions. The standard brain capillary isolation methods require the use of at least 5 mouse brains in order to obtain a sufficient amount and purity of bra...
ORGANISM(S): Mus Musculus (mouse) 
2023-07-12 | PXD041770 | JPOST Repository
ProteomicsProteome analysis of neonatal mouse brain and brain capillaries
The functions and protein expressions of the blood-brain barrier are changed during brain development after birth. The purpose of the present study was to develop a method to isolate brain capillaries from a single frozen neonatal mouse brain and elucidate the enrichment of brain capillaries by quan...
ORGANISM(S): Mus Musculus (mouse) 
2023-07-12 | PXD039296 | JPOST Repository
ProteomicsRat liver treated by PCN
The combination analyses of transcriptomics, proteomics, phosphoproteomics, and metabolomics in rat liver after repeated oral doses of PXR agonist, PCN, for 7 days were conducted to understand the roles for PXR on non-genotoxic signaling and energy homeostasis. mRNA and proteins in homogenate supern...
ORGANISM(S): Rattus Rattus (black Rat) 
2018-01-01 | PXD006305 | JPOST Repository
ProteomicsProteome study to optimize Zeno SWATH DIA
Data-independent acquisition (DIA) techniques, such as SWATH acquisition, have emerged as the preferred strategy for proteomic analysis. Our study optimizes the SWATH-DIA method using a narrow isolation window placement approach improving its proteomic performance. We optimized the acquisition param...
ORGANISM(S): Homo Sapiens (human) Cellular Organisms Mus Musculus (mouse) 
2024-07-20 | PXD050030 | JPOST Repository
ProteomicsBlood-brain barrier proteomics
Brain microvessels (BMVs) were isolated from frozen human and mouse cerebral cortices, as well as frozen mouse cerebrums. BMVs and cultured brain microvascular endothelial cells (BMECs), such as hCMEC/D3, HBMEC/ci, and primary BMECs, were analyzed via data-independent acquisition using liquid chrom...
ORGANISM(S): Homo Sapiens (human) Cellular Organisms Mus Musculus (mouse) 
2025-07-23 | PXD060008 | JPOST Repository
ProteomicsHuman tissue microsomed by MRM, MRMHR and SWATH
The purpose of the present study was to examine simultaneously the absolute protein amounts of 152 membrane and membrane-associated proteins, including 30 metabolizing enzymes and 107 transporters, in pooled microsomal fractions of human liver, kidney and intestine by means of SWATH-MS with stable i...
ORGANISM(S): Homo Sapiens (human) 
2018-01-01 | PXD008265 | JPOST Repository
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