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Clinical score and transcript abundance patterns identify Kawasaki disease patients who may benefit from addition of methylprednisolone. Intravenous immunoglobulin (IVIG) treatment-resistant patients are high risk of developing coronary artery lesions (CALs) with Kawasaki disease (KD). The IVIG-resp...
ORGANISM(S): Homo sapiens 
Intravenous immunoglobulin (IVIG) is a first-line drug prepared from human plasma for the treatment of autoimmune diseases (AID), especially immune thrombocytopenia (ITP). Since significant differences exist in protein types and expression levels between male and female plasma, and the prevalence of...
ORGANISM(S): Mus Musculus 
2023-09-26 | PXD045681 |
IVIg mitigates radiation injury.
Effect of IVIG on the activation of plasmacytoid dendritic cells
We systematically assessed the transcriptomic changes of lipopolysaccharides (LPS) of mice upon stimulation with immunoglobulins (IVIg), modified immunoglobulins (modIVIg) or vehicle controls in kidney, blood and liver in vivo. Data indicate different in vivo responses to LPS in conjunction with IVI...
ORGANISM(S): Mus musculus 
In this study, a mouse model of dextran sulfate sodium (DSS)-induced colitis was employed to investigate the role and mechanism of IVIG by proteomics.
ORGANISM(S): Mus musculus (Mouse) 
2026-07-28 | PXD068491 | Pride
To investigate the effect of IVIG and desialylated IVIG on the activation of plasmacytoid dendritic cells (pDCs). Human primary plasmacytoid dendritic cells were treated with TLR stimulation together with or without IVIG or desialylated IVIG, and the change of genes were analyzed. Primary human pDCs...
ORGANISM(S): Homo sapiens 
2022-07-04 | GSE207028 | GEO
Identification of IVIg regulated genes in human peripheral blood monocytes by gene expression analysis before and after IVIg infusion in CVID patients [CD3]
Identification of IVIg regulated genes in human peripheral blood B cells by gene expression analysis before and after IVIg infusion in CVID patients [CD20]
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