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ProteomicsMS-based proteomics in HUVECs transfecting with IVT mRNA
The therapeutic success of in vitro-transcribed (IVT) mRNA depends on its stability and efficient translation. However, IVT mRNA is highly susceptible to immune-mediated degradation, limiting its efficacy. To investigate the binding protein profiles of IVT mRNA, we transfected HUVECs with 4SU-modifi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD061961 | Pride
Lc-ms/ms Huvecs Ivt mrna 
TranscriptomicsIVT-seq reveals extreme bias in RNA-sequencing
Background RNA sequencing (RNA-seq) is a powerful technique for identifying and quantifying transcription and splicing events, both known and novel. However, given its recent development and the proliferation of library construction methods, understanding the bias it introduces is incomplete but cri...
ORGANISM(S): Homo sapiens 
2014-05-21 | E-GEOD-50445 | biostudies-arrayexpress
Proteomics5′ terminal nucleotide determines the immunogenicity of IVT RNAs
In vitro transcription (IVT) is a technology of vital importance that facilitated the production of mRNA therapeutics and drove numerous breakthroughs in RNA biology. T7 polymerase-produced RNAs can begin with either 5′-triphosphate guanosine (5′-pppG) or 5′-triphosphate adenosine (5′-pppA), generat...
ORGANISM(S): Homo sapiens (Human) 
2025-02-18 | PXD057761 | Pride
Innate immunity Ivt Dsrna Rig-i 
GenomicsMutational analysis of IVT mRNAs
Mutational analysis of IVT mRNAs
PRJNA924758 | ENA
GenomicsPyBo-seq of IVT RNA
PyBo-seq of IVT RNA
PRJNA1314584 | ENA
GenomicsIVT-seq reveals extreme bias in RNA-sequencing
IVT-seq reveals extreme bias in RNA-sequencing
PRJNA217498 | ENA
Transcriptomics3' UTR RNA-sequencing of human lung adenocarcinoma cell lines PC9 and A549 treated with RIG-I agonist IVT4/unspecific control IVT-GAC
The cell lines were treated with RIG-I agonist IVT4 or unspecific control IVT-GAC for 8h and then harvested for 3' UTR RNA-seq analysis
ORGANISM(S): Homo sapiens 
2021-08-09 | E-MTAB-10802 | biostudies-arrayexpress
Unknown5' terminal nucleotide determines the immunogenicity of IVT RNAs.
Not available
S-EPMC11797061 | biostudies-literature
GenomicsTranscriptomic profiling of interferon responses induced by IVT sgRNAs in CRISPRi HEK293T cells
Transcriptomic profiling of interferon responses induced by IVT sgRNAs in CRISPRi HEK293T cells
PRJNA1415764 | ENA
UnknownQuestionnaire for the assessment of adherence barriers of intravitreal therapy: the ABQ-IVT.
Not available
S-EPMC8170736 | biostudies-literature
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