Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains
Gene expression patterns were investigated in well-defined genetically cerebral malaria-resistant (CM-R) and cerebral malaria-susceptible (CM-S) mouse strains. cDNA microarrays were used to search for differentially expressed genes in mouse brain. Four mouse strains, known to differ in susceptibilit...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-370 | biostudies-arrayexpress
TranscriptomicsEffect of hepatocyte-restricted deletion of fgf21 deletion on liver gene expression in response to fasting in mice
FGF21 is a liver-derived hormone potently induced in response to fasting. However, its role in the regulation of hepatic gene expression is unknown. The effect of 20h fasting on liver gene expression was investigated in wild-type mice and in mice lacking hepatocyte FGF21. Fgf21 hepatocyte-specific ...
ORGANISM(S): Mus musculus 
2026-10-16 | E-MTAB-15848 | biostudies-arrayexpress
TranscriptomicsEffect of hepatocyte FGF21 on brown adipose tissue gene expression in mice
FGF21 is an hepatokine, a liver-derived hormone, that is highly induced and secreted in response to fasting. We investigated the role of hepatic FGF21 on gene expression profile in the brown adipose tissue. The effect of 20h fasting on brown adipose tissue gene expression was investigated in male wi...
ORGANISM(S): Mus musculus 
2026-10-17 | E-MTAB-15855 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of brain tissue from cerebral malaria-resistant and susceptible strains of mice in a time series following infection with Plasmodium berghei
Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (...
ORGANISM(S): Mus musculus 
2007-05-01 | E-MEXP-1018 | biostudies-arrayexpress
TranscriptomicsThe 1918 PB2 protein, not HA, enhances the virulence of an avian influenza virus closely related to the 1918 pandemic virus through the inhibition of wnt signaling.
The purpose of this experiment was to understand the pathogenic role of individual 1918 genes on the host response to the 1918 pandemic influenza virus. We examined reassortant avian viruses nearly identical to the pandemic 1918 virus (1918-like avian virus) carrying either the 1918 HA or PB2 gene....
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-70502 | biostudies-arrayexpress
TranscriptomicsPeriosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin
Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain poorly characterized. Here, we show that periosteum contains SSCs with high bone regenerative potential compared to bone marrow stromal cells/skeletal stem cells (BMSCs) in mice. Although periosteal cells (PCs...
ORGANISM(S): Mus musculus 
2018-10-18 | E-MTAB-6417 | biostudies-arrayexpress
ProteomicsThe dual prey-inactivation strategy of spiders - In-depth venomic analysis of Cupiennius salei
Most knowledge on spider venoms concerns neurotoxins acting on ion channels, whereas proteins and their significance for the envenomation process are neglected. The comprehensive analysis presented here of the venom gland transcriptome and proteome of Cupiennius salei with a focus on proteins and cy...
ORGANISM(S): Cupiennius salei (American wandering spider) 
2019-03-25 | PXD012881 | Pride
Cupiennius salei spider venom 
UnknownA DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.
Not available
S-EPMC4005274 | biostudies-literature
TranscriptomicsEvidence of Dynamically Dysregulated Gene Expression Pathways in Hyper-responsive B Cells from African American Lupus Patients
In this report we applied standard and original methods of analysis of gene expression microarray data to delineate differences in the molecular pathways impacted by stimulation of Epstein-Barr virus (EBV) transformed B cells derived from patients with systemic lupus erythematosus (SLE) and normal u...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37573 | biostudies-arrayexpress
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
Sort   by:  
 Page size