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ProteomicsSelective Gas Phase Enrichment of Modified Peptides for Activity-Based Protein Profiling
Gas phase enrichment separates ionized peptides by their physicochemical properties, offering both simplified sample processing and integration with existing MS technology. We leveraged differential ion mobility of labeled peptides to develop a gas phase enrichment approach for reactive amino acid p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-03 | MSV000095231 | MassIVE
ProteomicsGlobal Protein-Ligand Binding Affinity Profiling via Photocatalytic Labeling
Submission for manuscript "Global Protein-Ligand Binding Affinity Profiling via Photocatalytic Labeling" Files contained within the folder "Raw MS Files" are raw spectrum files (.d) from a timsTOF Pro 2 mass spectrometer, these files were processed using DIANN using the provided FASTA file and in si...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-15 | MSV000096433 | MassIVE
ProteomicsPhenotypic screening against P. falciparum under physiologically relevant nutrients levels reveals novel chemical diversity and highlights the importance of the PSAC channel for parasite survival.
Microenvironment mapping was used to identify the binding targets of two small molecules in Plasmodium Falciparum cells. In the method, small molecule - photocatalyst conjugates sensitize biotinylation of proteins binding the small molecules, which were reduced, alkylated with iodoacetamide, and imm...
ORGANISM(S): Plasmodium Falciparum (ncbitaxon:5833) 
2024-07-04 | MSV000095249 | MassIVE
Proteomicsnano-LC/MS/MS analysis of Human Mesenteric lymph endogenous peptidome isolated from Inflammatory Bowel Disease (IBD) subjects.
A compromised pathology of the intestinal barrier have been associated with a series of inflammatory conditions where the routine controls nutrient absorption and pathogens exclusion is lost to different degrees. When the epithelial barrier is compromised, bacteria and their products can attack the ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD051024 | Pride
Lyph Peptidome Inflammatory bowel disease 
ProteomicsLabel-free quantitative data dependent (DDA) nano-LC-MS/MS analysis of proteomic changes in the mesenteric lymph harvested from healthy (control) and DSS-fed mice models of colitis
The gastrointestinal mucosa constitutes a critical barrier where millions of microbes and environmental antigens can interact with the host immune system. Intestinal barrier defects have been linked to a broad range of pathological states, including autoimmune, cancer and neurodegenerative diseases....
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD044885 | Pride
Mouse mesenteric lymph  dda nano-lc/ms/ms 
ProteomicsLabel free-DDA nano-LC/MS/MS analysis of Human Mesenteric lymph collected from Inflammatory Bowel Disease (IBD) subjects.
Compromise of the intestinal barrier have been associated with a series of inflammatory conditions where the routine controls nutrient absorption and pathogens exclusion is lost to different degrees. The intestinal epithelial cells form a barrier of selective permeability which protects from invasio...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044801 | Pride
Lable free-dda Lymphatics Inflammatory bowel disease Lymph 
UnknownRole of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load.
Not available
S-EPMC11233987 | biostudies-literature
ProteomicsMicroMap photoproximity labeling enables small molecule binding site mapping
Proteomics data for MicroMap enabled binding site mapping
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-26 | MSV000092043 | MassIVE
UnknownTemporal trends in the use of targeted temperature management after cardiac arrest and association with outcome: insights from the Paris Sudden Death Expertise Centre.
Not available
S-EPMC6892202 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
Not available
S-EPMC8362592 | biostudies-literature
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