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ProteomicsTargeting of Tumor Cells by the Adenovirus E4orf4 protein via Par3 Polarity Protein-Regulated Nuclear Envelope Rupture
The protein product of the Early region 4 open reading frame 4 (E4orf4) of human adenovirus 2 is reported to exhibit a tumor-selective cell killing activity. Here, we show that E4orf4’s tumoricidal activity correlated with changes in perinuclear actomyosin contractility that are controlled by an in...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014329 | Pride
Lamin a/c Polarity proteins Actin Live cell dynamics Nuclear bleb E4orf4 
UnknownUse of Nalmefene in Routine Practice: Results from a French Prospective Cohort Study and a National Database Analysis.
Not available
S-EPMC8406069 | biostudies-literature
UnknownA novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major.
Not available
S-EPMC6534544 | biostudies-literature
UnknownS100A14 as a Potential Biomarker of the Colorectal Serrated Neoplasia Pathway
Not available
S-EPMC12347601 | biostudies-literature
UnknownMolecular evolution of Azagny virus, a newfound hantavirus harbored by the West African pygmy shrew (Crocidura obscurior) in Cote d'Ivoire.
Not available
S-EPMC3163557 | biostudies-literature
ProteomicsIdentification of non-overlapping functions between adaptor proteins NCK1 and NCK2
Signals from cell surface receptors are often relayed via adaptor proteins. NCK1 and NCK2 are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a remodelling of the actin cytoskeleton. Evidence from gene inactivation in mouse suggest that NCK1 and NCK2 are functionally redu...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD008824 | Pride
Mass spectrometry Nck adaptors Specificity 
TranscriptomicsTranscription profiling by array of the effect of S78454, a pan histone deacetylase inhibitor, on megakaryopoiesis derived from human CD34+ cells
S78454 (Abexinostat, PCI-24781) is a pan histone deacetylase inhibitor (HDACi) that demonstrates efficacy in malignancy treatment. Like other HDACi, this drug induces a profound thrombocytopenia, whose mechanism is partially understood. We have tested its effect at doses reached in patients plasma o...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-MTAB-1180 | biostudies-arrayexpress
UnknownDuration of prone position sessions: a prospective cohort study.
Not available
S-EPMC7245995 | biostudies-literature
UnknownAutomated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING).
Not available
S-EPMC7374079 | biostudies-literature
ProteomicsThe ShcA adapter protein cooperates with LPP to mediate adhesion dynamics and invadopodia formation
ShcA and Lipoma Preferred Partner (LPP) are mediators of TGFβ-induced breast cancer cell migration and invasion. Reduced expression of either protein results in diminished breast cancer lung metastasis. Total internal reflection fluorescence (TIRF) microscopy reveals that TGFβ enhances the assembly ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-27 | PXD018265 | Pride
Invasion Shca Adhesion Adaptor 
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