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ProteomicsDevelopment of resistance to type II JAK2 inhibition in MPN depends on AXL kinase and is targetable
Purpose: Myeloproliferative neoplasms (MPN) dysregulate JAK2 signaling. Since clinical JAK2 inhibitors have limited disease-modifying effects, type II JAK2 inhibitors such as CHZ868 stabilizing inactive JAK2 and reducing MPN clones, gain interest. We studied whether MPN cells escape from type ll inh...
ORGANISM(S): Homo sapiens (Human) 
2023-11-07 | PXD039419 | Pride
: lfq Resistance Myeloproliferative neoplasms Mapk Chz868 Axl Phosphoproteomics Dda Jak2 inhibition 
TranscriptomicsAnalysis of mouse T cell transcription profile after co-culture with BaF3 cells with or without the oncogenic point mutation JAK2 V617F
The activation of PD-1 (Programmed Death receptor-1) on T cells can cause T cell exhaustion and immune tolerance. Some tumors up-regulate the expression of the ligand of PD-1, namely PD-L1 (Programmed Death Receptor-Ligand 1), thus preventing anti-tumor immune response and promoting immune-escape. P...
ORGANISM(S): Mus musculus 
2018-12-01 | E-MTAB-5028 | biostudies-arrayexpress
TranscriptomicsMurine Ba/F3 Cells: Ba/F3 cells expressing wild type JAK2 (WT cells) vs. Ba/F3 cells expressing JAK2 V617F mutant (VF cells)
Transcriptional profiling of transformed Ba/F3 cells by myeloproliferative neoplasm-associated JAK2 V617F mutant comparing control Ba/F3 cells expressing wild type JAK2. Two-condition experiment, WT cells vs. VF cells. One replicate per array.
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-34239 | biostudies-arrayexpress
TranscriptomicsCooperative Epigenetic Modulation by Cancer Amplicon Genes
Amplification of a ~2.5 megabase region on chromosome 9p24 is frequent in both primary mediastinal B-cell lymphoma (PMBL) and Hodgkin's lymphoma (HL). To identify the oncogenic genes in this interval, we created a RNA interference library targeting amplicon genes. A genetic screen using this library...
ORGANISM(S): Homo sapiens 
2011-01-04 | E-GEOD-20988 | biostudies-arrayexpress
ProteomicsSplicing factor Ybx1 maintains persistent Jak2-mutated neoplasms via Mknk1-ERK-signaling
Janus kinases (Jak) mediate cytokine, hormone and growth factor responses in hematopoietic cells. Jak2 is one of the most frequently mutated genes in the aging hematopoietic system and in hematopoietic cancers. Mutations in Jak constitutively activate downstream signaling and are drivers of myelopro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-20 | PXD006921 | Pride
Mpn Phosphoproteome Jak2 Hematological malignancy Splicing factor Erksignaling Ybx1 
GenomicsJAK2 inhibition in Philadelphia chromosome like acute lymphoblastic leukemia
JAK2 inhibition in Philadelphia chromosome like acute lymphoblastic leukemia
PRJNA548171 | ENA
TranscriptomicsBET Protein Inhibition shows Efficacy Against JAK2V617F-Driven Neoplasms
Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of MLL-fusion protein driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor...
ORGANISM(S): Homo sapiens 
2013-08-20 | E-MTAB-1817 | biostudies-arrayexpress
GenomicsDUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression (microarray)
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression (microarray)
PRJNA885065 | ENA
GenomicsDUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression (RNA-Seq)
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression (RNA-Seq)
PRJNA787454 | ENA
TranscriptomicsTranscription profiling of human fibrosarcoma cells to study the relative contributions of Jak1 and Jak2 in IFNg signaling
General impact of Jak1 and Jak2 inhibition on IFNg-mediated target gene expression. U4C-Jak1AS and g2A-Jak2AS cells were stimulated with IFNg and treated with either 1NM-PP1 (to inhibit the activity only of the analog-sensitive mutant) or JI1 (to suppress both wild-type and analog-sensitive Jaks) fo...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-MEXP-2621 | biostudies-arrayexpress
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