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MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
ProteomicsInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
We compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE2 production and increased PGF2α and throm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD013490 | Pride
Inflammation A549 Cancer Mpges-1 Lc-ms/ms 
UnknownCorrection: Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen.
Not available
S-EPMC5919627 | biostudies-literature
UnknownTargeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis.
Not available
S-EPMC5932839 | biostudies-literature
UnknownDescriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids.
Not available
S-EPMC7376893 | biostudies-literature
UnknownInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.
Not available
S-EPMC6567928 | biostudies-literature
UnknownPharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with 18F-Labeled Derivatives in Rats.
Not available
S-EPMC7497404 | biostudies-literature
UnknownInhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.
Not available
S-EPMC6021299 | biostudies-literature
UnknownBiological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone.
Not available
S-EPMC6965680 | biostudies-literature
UnknownTwo subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjogren's syndrome differ in molecular signatures and treatment perspectives.
Not available
S-EPMC6378708 | biostudies-literature
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