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UBR4 was identified as a potential oncogene in lung adenocarcinoma (LUAD). In this study, we performed a quantitative proteomics analysis using tandem mass tag (TMT) 6-plex technology in UBR4 knockout A549 cell lines to discover an essential role of UBR4 in tumor growth and metastasis.
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD051417 | Pride
A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the “Warburg effect”, which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation of SIRT1 is...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD006036 | Pride
Affymetrix SNP6.0 breast cancer genome sequencing data
We propose to definitively characterise the somatic genetics of breast cancer through generation of comprehensive catalogues of somatic mutations in breast cancer cases by high coverage genome sequencing coupled with integrated transcriptomic and methylation analyses.
We propose to definitively characterise the somatic genetics of breast cancer through generation of comprehensive catalogues of somatic mutations in breast cancer cases by high coverage genome sequencing coupled with integrated transcriptomic and methylation analyses.
A comprehensive characterisation and analysis of human breast cancers through whole-genome sequencing.
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