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TranscriptomicsSafety assessment of novel foods using omics profiling combined with one-class classifiers
Food safety evaluation of new, genetically modified (GM) plant varieties has led to basic questions regarding the safety assessment of new plant varieties and whole foods derived thereof. An important part of the hazard identification in the European approach is a targeted compositional analysis of ...
ORGANISM(S): Solanum tuberosum 
2014-03-04 | E-MTAB-1707 | biostudies-arrayexpress
ProteomicsPCID2 regulates HIV-1 transcription and viral RNA processing during latency
HIV-1 latency results from a combination of tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. In an effort to elucidate the molecular players that govern viral latency, we previously performed a dCas9 chromatin immunoprecipitation coupled with mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043334 | Pride
Pcid2 regulates hiv-1 transcription and viral rna processing during latency 
ProteomicsProteomic Analysis of Urinary Extracellular Vesicles from Patients with ADTKD-HNF1β identifies roles for cilia-related proteins and Serpins
Autosomal dominant tubulointerstitial kidney disease-subtype hepatocyte nuclear factor 1β (ADTKD-HNF1β) is caused by pathogenic variants in or deletions of the gene encoding transcription factor HNF1β. Patients with the same mutation have variable renal and extrarenal phenotypes, including renal cys...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD050720 | Pride
Urine Cilia Serpins Ckd Extracellular vesicles Adpkd Adtkd-hnf1b 
ProteomicsTCR-engineered T-cells directed against Ropporin-1 constitute a safe and effective treatment for triple-negative breast cancer in near-clinical models
Triple-negative breast cancer (TNBC) shows an urgent need for new therapies. We discovered Ropporin 1 (ROPN1) as a target to treat TNBC with T-cells. ROPN1 showed high and homogenous expression in 90% of primary and metastatic TNBC but not in healthy tissues. HLA-A2-binding peptides were detected v...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054804 | Pride
Adoptive t-cell therapy  cross-reactivity  epitopes  gene-engineering  immunopeptidomics  ropporin-1  t-cell receptor  triple negative breast cancer  tumor-restricted antigen 
ProteomicsTMX2 is a key regulator of cellular redox state and its dysfunction causes severe brain developmental abnormalities.
The redox state of the neural progenitors regulates physiological processes such as neuronal differentiation, dendritic and axonal growth. The relevance of ER-associated oxidoreductases in these processes is largely unexplored. We describe a severe neurological disorder caused by biallelic loss of f...
ORGANISM(S): Homo sapiens (Human) 
2019-11-19 | PXD014064 | Pride
Tmx2 Brain developmental abnormalities Redox state 
UnknownBridging hospital to home for children with medical complexity and their families: an observational prospective cohort study protocol to assess the effectiveness of an innovative transitional care unit in the Netherlands (BRIDGE study).
Not available
S-EPMC12010278 | biostudies-literature
UnknownLongitudinal echocardiographic and clinical follow-up of patients undergoing mitral valve surgery without concomitant tricuspid valve repair.
Not available
S-EPMC6220025 | biostudies-literature
MetabolomicsSearching for metabolic changes in urine headspace composition as an effect of strenuous walking
The present investigation uses proton transfer reaction mass spectrometry (PTR-MS) combined with multivariate and univariate statistical analyses to study potential biomarkers for altered metabolism in urine due to strenuous walking. Urine samples, in concurrence with breath and blood samples, were ...
2016-12-14 | MTBLS164 | MetaboLights
UnknownEssential diseases in prescribing: A national Delphi study towards a core curriculum in pharmacotherapy education.
Not available
S-EPMC6177701 | biostudies-literature
UnknownClinical Characteristics of Patients Undergoing Right Heart Catheterizations in Community Hospitals.
Not available
S-EPMC9496424 | biostudies-literature
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