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ProteomicsTargeting mitophagy in SRSF2 mutant hematologic malignancies
Recurrent Glycogen synthase kinase-3 (GSK-3) phosphorylates multiple splicing factors, including SRSF2, and regulates the splicing of a broad range of mRNAs in human cells. Inhibition of GSK-3 disrupts splicing and promotes cell death in hematopoietic cells with heterozygous mutations in SRSF2 and n...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD043213 | Pride
Mitophagy Chronic myelomonocytic leukemia (cmml) Myelodysplasia Srsf2 Acute myeloid leukemia Splicing Nonsense mediated decay Gsk-3 Pink1 
ProteomicsHepatocyte mitochondrial NAD+ content is limiting for liver regeneration
Supplemental NAD+ precursors show metabolic and functional benefits in rodent models of disease and are being explored as potential therapeutics in human studies. However, the wide range of processes that involve NAD+ in every cell and subcellular compartment make it difficult to narrow down mechani...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-08-15 | MSV000098839 | MassIVE
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
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