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TranscriptomicsEffect of SRSF2 over-expression in a human lung carcinoma cell line
We showed that the over-expression of the SR protein SRSF2 led to the regulation of transcript abundance of many genes. H358 cell line with 6 samples with SRSF2 over-expression and 6 samples as control.
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-50467 | biostudies-arrayexpress
TranscriptomicsSRSF2 is essential for hematopoiesis and its myelodysplastic syndromes-related mutations dysregulate alternative pre-mRNA splicing
We report the biological function of Srsf2 in hematopoiesis in conditional knockout mouse models. Ablation of Srsf2 in the hematopoietic lineage caused embryonic lethality, and Srsf2-deficient fetal liver cells showed significantly enhanced apoptosis and decreased hematopoietic stem/progenitor cells...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-61052 | biostudies-arrayexpress
ProteomicsTargeting mitophagy in SRSF2 mutant hematologic malignancies
Recurrent Glycogen synthase kinase-3 (GSK-3) phosphorylates multiple splicing factors, including SRSF2, and regulates the splicing of a broad range of mRNAs in human cells. Inhibition of GSK-3 disrupts splicing and promotes cell death in hematopoietic cells with heterozygous mutations in SRSF2 and n...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD043213 | Pride
Mitophagy Chronic myelomonocytic leukemia (cmml) Myelodysplasia Srsf2 Acute myeloid leukemia Splicing Nonsense mediated decay Gsk-3 Pink1 
TranscriptomicsSR Proteins Collaborate with 7SK and Promoter-Associated Nascent RNA to Release Paused Polymerase
RNAP II is frequently paused near gene promoters in mammals and its transition to productive elongation requires active recruitment of P-TEFb, a cyclin-dependent kinase for RNAP II and other key transcription elongation factors. A fraction of P-TEFb is sequestered in an inhibitory complex containing...
ORGANISM(S): Mus musculus 
2013-05-09 | E-GEOD-45517 | biostudies-arrayexpress
GenomicsNext-generation sequencing analysis of 7-month-old SRSF2 flox/flox and SRSF2-PKO mice pancreatic islet transcriptome
Next-generation sequencing analysis of 7-month-old SRSF2 flox/flox and SRSF2-PKO mice pancreatic islet transcriptome
PRJNA734367 | ENA
GenomicsSRSF2 mutations impair hematopoiesis and alter exon recognition
SRSF2 mutations impair hematopoiesis and alter exon recognition
PRJNA273749 | ENA
GenomicsSRSF2 transcriptional function maintains genome integrity during cell division
SRSF2 transcriptional function maintains genome integrity during cell division
PRJNA914312 | ENA
TranscriptomicsGenome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
SR proteins are well-characterized RNA binding proteins that promote exon inclusion by binding to exonic splicing enhancers (ESEs). However, it has been unclear whether regulatory rules deduced on model genes apply generally to activities of SR proteins in the cell. Here, we report global analyses o...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-44591 | biostudies-arrayexpress
GenomicsSRSF2 is required for mRNA splicing and spermatogenesis [LACE-seq]
SRSF2 is required for mRNA splicing and spermatogenesis [LACE-seq]
PRJNA851348 | ENA
GenomicsSRSF2 is required for mRNA splicing and spermatogenesis [RNA-seq]
SRSF2 is required for mRNA splicing and spermatogenesis [RNA-seq]
PRJNA851349 | ENA
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