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ProteomicsGABA, glucose and insulin orchestrate CD4+ T cells effector functions
Metabolic programs of immune cells are closely linked to their effector functions , where physiological molecules provide environmental cues and guidance. Exactly how it happens is still being unraveled. Insulin maintains normal blood glucose levels and glucose is themain source of energy and a prec...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD041654 | Pride
Cd4 Gaba 
ProteomicsRNA interactome capture in Escherichia coli globally identifies RNA-binding proteins
RNA-binding proteins (RPBs) are deeply involved in many fundamental cellular processes in bacteria and are vital for their survival. Despite this, few studies have so far been dedicated to globally identifying bacterial RBPs. We have adapted the RNA interactome capture (RIC) technique, originally de...
ORGANISM(S): Escherichia coli 
2023-03-30 | PXD032939 | Pride
Lc-ms Rna interactome capture Escherichia coli 
ProteomicsEffects of pro-opiomelanocortin neuropeptides on immunological pathways mediated by the melanocortin 3 receptor revealed by label-free quantitative thermal proteome profiling
In a thermal proteome profiling experiment we have identified 300 unique proteins that become thermally stabilized or destabilized downstream of signal activation of the melanocortin 3 receptor (MC3R) when expressed in HEK293 cells. Upon stimulation with either one of the endogenous MC3R-agonists AC...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039945 | Pride
Mc3r Tpp Label-free quantitation Pomc 
ProteomicsRegulating hippocampal levels of Alzheimer´s disease-related proteins with a brain-penetrating somatostatin peptide
Plaques consisting of amyloid-β (Aβ) in the brain are characteristic for patients with Alzheimer´s disease. Aβ is enzymatically generated of the amyloid precursor protein. Furthermore, neprilysin, an Aβ-degrading enzyme, and its main activator the neuropeptide somatostatin (SST) are d...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD022221 | Pride
Alzheimerã‚â´s disease Tryptic digestion Brain Lc-ms Mice Neprilysin Sst-scfv8d3 Amyloid-ãžâ² 
ProteomicsIntegrating Cell Painting and Thermal Proteome Profiling for Inference of Targets and Mechanism of Action
Understanding the mechanism of action (MoA) of bioactive compounds is a central challenge in drug discovery and chemical biology. In this article, we propose a strategy for integrating morphological data with proteomics to provide deeper insights into the MoA of compounds. We combine the rich phenot...
ORGANISM(S): Homo sapiens (Human) 
2025-12-18 | PXD065743 | Pride
Thermal proteome profiling Mechanism of action Drug target Cell painting 
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