Sort   by:  
 Page size 
UnknownEffectiveness of a clinical decision support system for reducing the risk of QT interval prolongation in hospitalized patients.
Not available
S-EPMC4696749 | biostudies-literature
Proteomicsc-Met activation leads to the establishment of a TGFβ receptor regulatory network required for bladder cancer invasion
Treatment of muscle-invasive bladder cancer remains a major clinical challenge. Aberrant HGF/c-MET upregulation and activation is frequently observed in bladder cancer correlating with cancer progression and invasion. However, the precise mechanisms underlying HGF/c-MET mediated invasion in bladder ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD014736 | Pride
C-met Emt Bladder cancer invasion Phosphorylation Tgfb Smurf2 
UnknownDrug-induced QT interval prolongation in patients with heart failure with preserved ejection fraction.
Not available
S-EPMC11332914 | biostudies-literature
UnknownPostsynaptic expression of tetanus toxin light chain blocks synaptogenesis in Drosophila.
Not available
S-EPMC2726806 | biostudies-literature
ProteomicsStructural and functional characterization of ubiquitin variant inhibitors of USP15
The multi-domain deubiquitinase USP15 regulates diverse eukaryotic processes and has been implicated in numerous diseases. We developed ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three adaptor domains in USP15, including the N-terminal DUSP domain. Taking advantag...
ORGANISM(S): Homo sapiens (Human) 
2019-01-16 | PXD011840 | Pride
Usp15 
ProteomicsPLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the clinical development of PLK1 inhibitors has been hampered by the lack of patient selection marker. Using a high-...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD031110 | Pride
Oxidative phosphorylation Mitochondria Plk1 Arid1a Synthetic lethality 
UnknownBRAFV600E accelerates disease progression and enhances immune suppression in a mouse model of B-cell leukemia.
Not available
S-EPMC5737117 | biostudies-literature
UnknownThe Safety of Deutetrabenazine for Chorea in Huntington Disease: An Open-Label Extension Study.
Not available
S-EPMC9653309 | biostudies-literature
UnknownPatterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma.
Not available
S-EPMC10157367 | biostudies-literature
UnknownMannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses.
Not available
S-EPMC7832040 | biostudies-literature
Sort   by:  
 Page size