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ProteomicsStructural and functional characterization of ubiquitin variant inhibitors of USP15
The multi-domain deubiquitinase USP15 regulates diverse eukaryotic processes and has been implicated in numerous diseases. We developed ubiquitin variants (UbVs) that targeted either the catalytic domain or each of three adaptor domains in USP15, including the N-terminal DUSP domain. Taking advantag...
ORGANISM(S): Homo sapiens (Human) 
2019-01-16 | PXD011840 | Pride
Usp15 
TranscriptomicsRNA-Sequencing of USP15 knock-out mice injected with kainate
Transcriptome studies of brain resections from mesial temporal lobe epilepsy (mTLE) patients revealed a dysregulation of transforming growth factor (TGF)-β, interferon (IFN)-α/β and nuclear factor erythroid 2-related factor 2 (NRF2) pathways among other neuroinflammatory mechanisms. Since ubiquitin-...
ORGANISM(S): Mus musculus 
2023-10-12 | E-MTAB-12633 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing of USP15 conditional knock-out mice injected with kainate - dataset 2
Transcriptome studies of brain resections from mesial temporal lobe epilepsy (mTLE) patients revealed a dysregulation of transforming growth factor (TGF)-β, interferon (IFN)-α/β and nuclear factor erythroid 2-related factor 2 (NRF2) pathways among other neuroinflammatory mechanisms. Since ubiquitin-...
ORGANISM(S): Mus musculus 
2023-10-12 | E-MTAB-12634 | biostudies-arrayexpress
ProteomicsUSP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells
To decipher the role of USP15 in DNA damage in leukemia cells, endogenous USP15 was immunoprecipitated from MV4-11 and Kasumi-1 cell lines under naive and DNA stress conditions (Mitomycin C, 30nM, 1h). 355 candidates co-immunoprecipitated with USP15 in all the conditions, in 4 independent experiment...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD020612 | Pride
Human Dna damage Ubiquitin 
ProteomicsThe CRL3gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins
Giant axonal neuropathy (GAN) is caused by mutations in the GAN gene encoding for gigaxonin (GIG), which functions as an adaptor of the CUL3-RBX1-GIG (CRL3GIG) E3 ubiquitin ligase complex. The pathological hallmark of GAN is characterized by the accumulation of densely packed neurofilaments (NFs) in...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD042592 | Pride
Usp15 Gan Gigaxonin Neurofilament 
GenomicsRNA-Sequencing of USP15 knock-out mice injected with kainate
RNA-Sequencing of USP15 knock-out mice injected with kainate
PRJEB59928 | ENA
GenomicsRNA-Sequencing of USP15 conditional knock-out mice injected with kainate - dataset 2
RNA-Sequencing of USP15 conditional knock-out mice injected with kainate - dataset 2
PRJEB59933 | ENA
GenomicsIn vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
In vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
PRJNA910197 | ENA
TranscriptomicsIn vivo CRISPR screens reveal SCAF1 and USP15 as novel drivers of pancreatic cancer
Functionally characterizing the genetic alterations that drive pancreatic cancer progression is a prerequisite for precision pedicine. Here, we developed a somatic CRISPR/Cas9 mutagenesis screen to assess the transforming potential of 125 recurrently mutated ‘long-tail’ pancreatic cancer genes, whic...
ORGANISM(S): Mus musculus 
2024-03-31 | GSE220556 | GEO
TranscriptomicsQuantitative Analysis by Next Generation Sequencing of LSK (Lin- Sca1+ cKit+) hematopoietic progenitors transcriptomes from wild type and Usp15-/- mice.
Purpose: the goal of this study is to investigate the consequences of ubiquitin specific protease 15 (USP15) deletion on gene expression in mouse LSK hematopoietic progenitors. Methods: mRNA profiles of 8 weeks-old wild-type (WT) and ubiquitin specific protease 15 knockout (Usp15−/−) mice were gener...
ORGANISM(S): Mus musculus 
2020-10-31 | GSE160525 | GEO
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