Sort   by:  
 Page size 
ProteomicsmTOR inhibition ameliorates tau burden and neurofilament pathology in sporadic PSP-RS neurons
Progressive supranuclear palsy, Richardson’s syndrome subtype (PSP-RS), is a tauopathy marked by early axonal pathology and neurodegeneration. Modeling sporadic PSP-RS in human neurons remained a major challenge. Here, we generated midbrain dopaminergic (mDA) neurons from induced pluripotent stem ce...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD072104 | Pride
Tauopathy  progressive supranuclear palsy  neurofilament  dopaminergic neurons  axonal degeneration  autophagy modulation 
GenomicsAutophagy enhancement ameliorates tau burden and neurofilament pathology in sporadic PSP-RS neurons
Autophagy enhancement ameliorates tau burden and neurofilament pathology in sporadic PSP-RS neurons
PRJNA1387361 | ENA
ProteomicsThe CRL3gigaxonin ubiquitin ligase-USP15 pathway governs the destruction of neurofilament proteins
Giant axonal neuropathy (GAN) is caused by mutations in the GAN gene encoding for gigaxonin (GIG), which functions as an adaptor of the CUL3-RBX1-GIG (CRL3GIG) E3 ubiquitin ligase complex. The pathological hallmark of GAN is characterized by the accumulation of densely packed neurofilaments (NFs) in...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD042592 | Pride
Usp15 Gan Gigaxonin Neurofilament 
TranscriptomicsAutophagy enhancement ameliorates tau burden and neurofilament pathology in sporadic PSP-RS neurons
Progressive supranuclear palsy, Richardson’s syndrome subtype (PSP-RS), is a tauopathy marked by early axonal pathology and neurodegeneration. Modeling sporadic PSP-RS in human neurons remained a major challenge. Here, we generated midbrain dopaminergic (mDA) neurons from induced pluripotent stem ce...
ORGANISM(S): Homo sapiens 
2026-01-30 | GSE313924 | GEO
UnknownPhosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis.
Not available
S-EPMC5676468 | biostudies-literature
GenomicsNeurofilament accumulations in Amyotrophic Lateral Sclerosis patients’ motor neurons impair structural axonal initial segment integrity
Neurofilament accumulations in Amyotrophic Lateral Sclerosis patients’ motor neurons impair structural axonal initial segment integrity
PRJNA824791 | ENA
GenomicsMicroglia influence neurofilament deposition in ALS iPSC-derived motor neurons
Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons
PRJNA793030 | ENA
GenomicsSecreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [bulkRNA-Seq]
Secreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [bulkRNA-Seq]
PRJNA1214826 | ENA
GenomicsSecreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [scRNA-Seq]
Secreted neurofilament light chain (NfL) after neuronal damage induces myeloid cell activation and neuroinflammation [scRNA-Seq]
PRJNA1214588 | ENA
GenomicsSerum neurofilament light reveals the contraction from widespread to lesion-bound neuroaxonal injury during autoimmune neuroinflammation
Serum neurofilament light reveals the contraction from widespread to lesion-bound neuroaxonal injury during autoimmune neuroinflammation
PRJNA940750 | ENA
Sort   by:  
 Page size