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ProteomicsTotal proteome analysis of WT vs TRAP1 KO in HCT-116 and HEK-293T cells grown on different carbon sources.
The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. To characterize the impact of TRAP1 in maintaining the cellular proteome under different energy sources we carried ou...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015828 | Pride
Oxidative phosphorylation Trap1 Mitochondrion Hsp90 Molecular chaperone 
ProteomicsThe mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis
The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) and an inducer of t...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015873 | Pride
Lc-ms Trap1 Silac Hsp90 paralog 
UnknownGenetic and transcriptomic dissection of the fiber length trait from a cotton (Gossypium hirsutum L.) MAGIC population.
Not available
S-EPMC6366115 | biostudies-literature
UnknownThe role of donor sex on the post-liver transplant outcomes in patients with primary sclerosing cholangitis.
Not available
S-EPMC10922567 | biostudies-literature
UnknownThe role of recipient sex in the post-liver transplant prognosis of acute-on-chronic liver failure
Not available
S-EPMC12140565 | biostudies-literature
TranscriptomicsJuvenile obesity in Ossabaw swine produces artery-specific transcriptional changes
We adopted a transcriptome-wide microarray analysis approach to determine the extent to which vascular gene expression is altered as a result of juvenile obesity and identify obesity-responsive mRNAs. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivas...
ORGANISM(S): Sus scrofa 
2013-05-29 | E-GEOD-41636 | biostudies-arrayexpress
TranscriptomicsCited-1 deficiency suppresses intestinal tumorigenesis through the repression of the Wnt pathway- evidence for the just right model of Wnt mediated tumorigenesis
Comparison of the expression profiles of the following genetically altered murine intestinal epithelium: AhCre wildtype, AhCre Apc floxed, AhCre Cited1 null and Ahcre Apcflx/Cited1 null.
ORGANISM(S): Mus musculus 
2012-05-05 | E-MEXP-3202 | biostudies-arrayexpress
UnknownATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.
Not available
S-EPMC5600837 | biostudies-literature
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
UnknownSuccinyl-5-aminoimidazole-4-carboxamide-1-ribose 5'-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form.
Not available
S-EPMC4995138 | biostudies-literature
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