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ProteomicsThe mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis
The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) and an inducer of t...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015789 | Pride
Oxidative phosphorylation Hsp90 Atp synthase Trap1 Molecular chaperone Mitochondria Glutamine Proteomics 
ProteomicsThe mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis
The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) and an inducer of t...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015873 | Pride
Lc-ms Trap1 Silac Hsp90 paralog 
TranscriptomicsTRAP1-related regulation of response to hypoxia in HCT116 colorectal cancer cells
TRAP1 is a HSP90 molecular chaperone involved in cancer cell adaptation to unfavorable environments and metabolic reprogramming. The role of TRAP1 in the adaptive response to hypoxia was investigated in human colorectal cancer.
ORGANISM(S): Homo sapiens 
2022-05-30 | E-MTAB-10563 | biostudies-arrayexpress
TranscriptomicsTRAP1 silencing in HCT116 cells
Trascription profiling analysis was performed on HCT-116 cell lines transiently silenced with TRAP1 compared with scrumble
ORGANISM(S): Homo sapiens 
2014-11-15 | E-MTAB-2500 | biostudies-arrayexpress
TranscriptomicsTRAP1 gene silencing in MCF7 cell lines
Transcription profiling by array of MCF7 cell lines silenced with TRAP1 small interfering RNA compared with scramble
ORGANISM(S): Homo sapiens 
2017-06-30 | E-MTAB-3584 | biostudies-arrayexpress
ProteomicsTotal proteome analysis of WT vs TRAP1 KO in HCT-116 and HEK-293T cells grown on different carbon sources.
The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. To characterize the impact of TRAP1 in maintaining the cellular proteome under different energy sources we carried ou...
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD015828 | Pride
Oxidative phosphorylation Trap1 Mitochondrion Hsp90 Molecular chaperone 
GenomicsTrap1 differentiated 3T3-L1 cells
Trap1 differentiated 3T3-L1 cells
PRJEB85703 | ENA
ProteomicsCoordinated regulation of metabolic plasticity by the Hsp90 chaperones
Heat shock protein 90 (Hsp90) chaperones participate in the stabilization and activation of hundreds of proteins, thereby acting as signaling hubs. A mitochondrial subpopulation of Hsp90 has been previously described; however, little is known about its role in metabolism. Here, we showed that loss o...
ORGANISM(S): Homo sapiens (Human) 
2026-05-01 | PXD069999 | Pride
Mitochondria Metabolism Post-translational modification Trap1 Molecular chaperone Heat-shock protein Hsp90 
GenomicsMutation in mitochondrial chaperone TRAP1 is responsible for male-specific autism
Mutation in mitochondrial chaperone TRAP1 is responsible for male-specific autism
PRJNA939632 | ENA
TranscriptomicsTransgenic Expression Of Mitochondrial Chaperone Trap1 Accelerates Prostate Cancer Development
Protein homeostasis, or proteostasis is critical for organelle function, including mitochondria, but its role in cancer is controversial. Here, we show that transgenic mice expressing the mitochondrial chaperone, TRAP1 in the prostate develop prostatic hyperplasia and cellular atypia. When examined ...
ORGANISM(S): Mus musculus 
2017-05-11 | GSE81316 | GEO
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