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UBR4 was identified as a potential oncogene in lung adenocarcinoma (LUAD). In this study, we performed a quantitative proteomics analysis using tandem mass tag (TMT) 6-plex technology in UBR4 knockout A549 cell lines to discover an essential role of UBR4 in tumor growth and metastasis.
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD051417 | Pride
Cystine-xCT transporter-Glutathione (GSH)-GPX4 axis is the canonical pathway to protect against ferroptosis. While not required for ferroptosis-inducing compounds (FINs) targeting GPX4, FINs targeting the xCT transporter require mitochondria and its lipid peroxidation to trigger ferroptosis. However...
ORGANISM(S): Homo sapiens (Human) 
2025-07-05 | PXD062566 | Pride
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